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Heterosynaptic phenomena are events that occur at the junctions (synapses) that form connections between neurons. A heterosynaptic phenomenon is one that involves interactions between separate synapses or groups of synapses. This term is often used in relation to long-term depression and long-term potentiation of neuronal firing. For example, heterosynaptic long-term depression occurs when neural activity involving one of a neuron's synapses causes the strength (the ability to transduce input) of another of the neuron's synapses to decrease.
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