The Hippo signaling pathway controls tissue growth in animals. Those animals that lack the pathway have overgrown body parts; the name Hippo comes from the 'hippopotamus-like' phenotype produced.
Known components of the pathway include:
- The receptor Fat, a cadherin which activates the pathway, and also seems to regulate planar cell polarity;[1]
- Merlin (Mer), an adaptor protein; and Expanded (Ex), an adaptor protein which acts in parallel with Mer;
- Hippo (Hpo) and Warts (Wts) kinases; and
- Yorkie (Yki), a transcription factor which upregulates genes responsible for cell proliferation and survival.
References
- ^ Willecke M, Hamaratoglu F, Sansores-Garcia L, Tao C, Halder G (September 2008). "Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation". PNAS 105 (39): 14897-902.
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Signaling pathway: Hippo signaling pathway |
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| Pathway components |
Fat · Merlin · Expanded · Hippo · Warts · Yorkie
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