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HLA-C

 
Wikipedia: HLA-C
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Major histocompatibility complex, class I, C
Illustation of an HLA-C showing the HLA-B 'alpha' chain, β2-Microglobulin, and the end of a peptide bound in the binding cleft.
Available structures: 1efx, 1im9, 1qqd
Identifiers
Symbols HLA-C; Cw*1701; D6S204; FLJ27082; HLA-JY3; HLC-C; PSORS1
External IDs OMIM: 142840 HomoloGene: 86715
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3107 667977
Ensembl ENSG00000204525 n/a
Uniprot P10321 n/a
Refseq XM_001131707 (mRNA)
XP_001131707 (protein)		 XM_001003863 (mRNA)
XP_001003863 (protein)
Location Chr 6: 31.34 - 31.35 Mb n/a
Pubmed search [1] [2]

HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.

HLA-C is a locus on chromosome 6 that encodes for a large number of HLA-C alleles that are Class-I MHC receptors. HLA-C is localized proximal to the HLA-B locus is located on the distal end of the HLA region. Most HLA Cw:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.

Contents

Disease Associations

By Serotype

Cw1: Multinodular goiters[1]

By Allele

Cw*16: B chronic lymphocytic leukaemia[2]

Nomenclature

Cw*01

  • Cw1 Serotype: Cw*0102 and Cw*0109
  • Cw11 ?
  • Cw*0104 to *0108


Cw*02

  • Cw2 Serotype: Cw*0202 and *0208
  • Cw*0203 to *0207, and 0209


Cw*03

  • Cw9 Serotype: Cw*0303
  • Cw10 Serotype: Cw*0302, *0304, and *0306
  • Cw3 Serotype: Cw*0307
  • Cw*0305 and 0308


Cw*04

  • Cw4 Serotype: Cw*0401, *0407, and *0410


Cw*05

  • Cw5 Serotype: Cw*0501 and *0502
  • Cw*0503 to *506 and *0508 to *0510


Cw*06

  • Cw6 Serotype: Cw*0602 and *0605
  • Cw6*0603, *0604 and *0606 to *0611


  • Cw7 Serotype: Cw*0701 to *0706, *0712, *0714, *0716
  • Cw*0707 to *0711, *0713, *0715, and *0717 to *0729


Cw*08

  • Cw8 Serotype: Cw*0801, *0802 and *0803
  • Cw*805 to *0812


Cw*1202 to *1215

Cw*1402 to *1405

Cw*1501 to *1511

Cw*1601 to *1606

Cw*1701 to *1703

Cw*1801 and *1802

Common Haplotype

Cw4-B35 (Western Africa to Native Americans) Cw7-B7 (Western Eurasia, South Africa) Cw7-B8 (Western Eurasia) Cw1-B46 (China, Indochina) Cw5-B44 (Western Eurasia)


Interactions

HLA-C has been shown to interact with KIR2DL1.[3][4][5][6]

References

  1. ^ Ríos A, Rodríguez J, Moya M, Galindo P, Canteras M, Alvarez M, Parrilla P (2006). "Associations of HLA-C alleles with multinodular goiters: study in a population from southeastern Spain.". Arch Surg 141 (2): 123–8. doi:10.1001/archsurg.141.2.123. PMID 16490887. 
  2. ^ Montes-Ares O, Moya-Quiles M, Montes-Casado M, Guerra-Pérez N, Campillo J, González C, López-Bermejo A, Tamayo M, Majado M, Parrado A, Muro M, Marín L, Alvarez-López M (2006). "Human leucocyte antigen-C in B chronic lymphocytic leukaemia.". Br J Haematol 135 (4): 517–9. doi:10.1111/j.1365-2141.2006.06334.x. PMID 17054674. 
  3. ^ Boyson, Jonathan E; Erskine Robert, Whitman Mary C, Chiu Michael, Lau Julie M, Koopman Louise A, Valter Markus M, Angelisova Pavla, Horejsi Vaclav, Strominger Jack L (Dec. 2002). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (25): 16180-5. doi:10.1073/pnas.212643199. ISSN 0027-8424. PMID 12454284. 
  4. ^ Baba, E; Erskine R, Boyson J E, Cohen G B, Davis D M, Malik P, Mandelboim O, Reyburn H T, Strominger J L (Dec. 2000). "N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors". Hum. Immunol. (United States) 61 (12): 1202-18. ISSN 0198-8859. PMID 11163076. 
  5. ^ Valés-Gómez, M; Reyburn H T, Mandelboim M, Strominger J L (Sep. 1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity (UNITED STATES) 9 (3): 337-44. ISSN 1074-7613. PMID 9768753. 
  6. ^ Fan, Q R; Long E O, Wiley D C (May. 2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex". Nat. Immunol. (United States) 2 (5): 452-60. doi:10.1038/87766. ISSN 1529-2908. PMID 11323686. 

Further reading

  • Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef.". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMID 11463741. 
  • Greenway AL, Holloway G, McPhee DA, et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.". J. Biosci. 28 (3): 323–35. doi:10.1007/BF02970151. PMID 12734410. 
  • Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris) 19 (1): 100–6. PMID 12836198. 
  • Leavitt SA, SchOn A, Klein JC, et al. (2004). "Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.". Curr. Protein Pept. Sci. 5 (1): 1–8. doi:10.2174/1389203043486955. PMID 14965316. 
  • Tolstrup M, Ostergaard L, Laursen AL, et al. (2004). "HIV/SIV escape from immune surveillance: focus on Nef.". Curr. HIV Res. 2 (2): 141–51. doi:10.2174/1570162043484924. PMID 15078178. 
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726. 
  • Anderson JL, Hope TJ (2005). "HIV accessory proteins and surviving the host cell.". Current HIV/AIDS reports 1 (1): 47–53. doi:10.1007/s11904-004-0007-x. PMID 16091223. 

External links

v • d • e
Surface antigens
Major histocompatibility complex/
Human leukocyte antigen
HLA-A • HLA-B • HLA-C • HLA-E • HLA-F • HLA-G
Other

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