HLA-DRB1

Major histocompatibility complex, class II, DR beta 1
Structure of HLA-DRB1 (green) complexed with HLA-DRA (cyan) and a fragment of HLA-A (magenta) based on the PDB 1AQD coordinates
Available structures
1aqd, 1bx2, 1d5m, 1d5x, 1d5z, 1d6e, 1dlh, 1fv1, 1fyt, 1h15, 1hqr, 1hxy, 1j8h, 1jwm, 1jws, 1jwu, 1kg0, 1klg, 1klu, 1lo5, 1pyw, 1r5i, 1seb, 1sje, 1sjh, 1t5w, 1t5x, 1ymm, 1zgl, 2fse, 2g9h, 2iam, 2ian, 2icw, 2ipk, 2oje, 2seb
Identifiers
Symbols	HLA-DRB1; DRB1; HLA DRB1; HLA-DR1B
External IDs	OMIM: 142857 MGI: 95901 HomoloGene: 85991
Gene ontology Molecular function • MHC class II receptor activity Cellular component • membrane • integral to membrane • MHC class II protein complex Biological process • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • immune response
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3123	14969
Ensembl	ENSG00000196126	ENSMUSG00000060586
UniProt	P01911	O19450
RefSeq	NM_002124 (mRNA)	NM_010382 (mRNA)
	NP_002115 (protein)	NP_034512 (protein)
Location	Chr 6: 32.65 - 32.67 Mb	Chr 17: 33.91 - 33.92 Mb
PubMed search	[1]	[2]

HLA class II histocompatibility antigen, DRB1-9 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene.^[1] DRB1 encodes the most prevalent beta subunit of HLA-DR.

Function

The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).^[1]

Gene structure and polymorphisms

The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.^[1]

Gene expression

DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.^[1]

See also

• HLA-DR

References

Further reading

v • d • e PDB Gallery 1aqd: HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITY PROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUS PEPTIDE   1bx2: CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101,DRB1*1501) COMPLEXED WITH A PEPTIDE FROM HUMAN MYELIN BASIC PROTEIN   1d5m: X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDE AND SEB   1d5x: X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH DIPEPTIDE MIMETIC AND SEB   1d5z: X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDOMIMETIC AND SEB   1d6e: CRYSTAL STRUCTURE OF HLA-DR4 COMPLEX WITH PEPTIDOMIMETIC AND SEB   1dlh: CRYSTAL STRUCTURE OF THE HUMAN CLASS II MHC PROTEIN HLA-DR1 COMPLEXED WITH AN INFLUENZA VIRUS PEPTIDE   1fv1: STRUCTURAL BASIS FOR THE BINDING OF AN IMMUNODOMINANT PEPTIDE FROM MYELIN BASIC PROTEIN IN DIFFERENT REGISTERS BY TWO HLA-DR2 ALLELES   1fyt: CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA-T CELL RECEPTOR, INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS II MOLECULE, HLA-DR1   1h15: X-RAY CRYSTAL STRUCTURE OF HLA-DRA1*0101/DRB5*0101 COMPLEXED WITH A PEPTIDE FROM EPSTEIN BARR VIRUS DNA POLYMERASE   1hqr: CRYSTAL STRUCTURE OF A SUPERANTIGEN BOUND TO THE HIGH-AFFINITY, ZINC-DEPENDENT SITE ON MHC CLASS II   1hxy: CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II   1j8h: Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor, Influenza HA Antigen Peptide, and MHC Class II Molecule, HLA-DR4   1jwm: Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1(HA peptide 306-318) with the Superantigen SEC3   1jws: Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1 (HA peptide 306-318) with the Superantigen SEC3 Variant 3B1   1jwu: Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1 (HA peptide 306-318) with the superantigen SEC3 Variant 3B2   1kg0: Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1   1klg: Crystal structure of HLA-DR1/TPI(23-37, Thr28-->Ile mutant) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)   1klu: Crystal structure of HLA-DR1/TPI(23-37) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)   1lo5: Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II   1pyw: Human class II MHC protein HLA-DR1 bound to a designed peptide related to influenza virus hemagglutinin, FVKQNA(MAA)AL, in complex with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)   1r5i: Crystal structure of the MAM-MHC complex   1seb: COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB   1sje: HLA-DR1 complexed with a 16 residue HIV capsid peptide bound in a hairpin conformation   1sjh: HLA-DR1 complexed with a 13 residue HIV capsid peptide   1t5w: HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR)   1t5x: HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR) and the superantigen SEC3-3B2   1ymm: TCR/HLA-DR2b/MBP-peptide complex   1zgl: Crystal structure of 3A6 TCR bound to MBP/HLA-DR2a   2fse: Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen   The maximum number of images (30) is exceeded !

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