HLA class I histocompatibility antigen, alpha chain F is a protein that in humans is encoded by the HLA-F gene.[1][2]
HLA-F belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-F binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 42 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. The HLA-F gene exhibits few polymorphisms.[2]
References
Further reading
- Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef.". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMID 11463741.
- Greenway AL, Holloway G, McPhee DA, et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.". J. Biosci. 28 (3): 323–35. PMID 12734410.
- Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris) 19 (1): 100–6. PMID 12836198.
- Leavitt SA, SchOn A, Klein JC, et al. (2004). "Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.". Curr. Protein Pept. Sci. 5 (1): 1–8. PMID 14965316.
- Tolstrup M, Ostergaard L, Laursen AL, et al. (2004). "HIV/SIV escape from immune surveillance: focus on Nef.". Curr. HIV Res. 2 (2): 141–51. PMID 15078178.
- Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. PMID 15638726.
- Anderson JL, Hope TJ (2005). "HIV accessory proteins and surviving the host cell.". Current HIV/AIDS reports 1 (1): 47–53. PMID 16091223.
- Kozlowski S, Corr M, Takeshita T, et al. (1992). "Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules.". J. Exp. Med. 175 (6): 1417–22. PMID 1316930.
- Lury D, Epstein H, Holmes N (1991). "The human class I MHC gene HLA-F is expressed in lymphocytes.". Int. Immunol. 2 (6): 531–7. PMID 1707659.
- Takahashi H, Merli S, Putney SD, et al. (1989). "A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160.". Science 246 (4926): 118–21. PMID 2789433.
- Dianzani U, Bragardo M, Buonfiglio D, et al. (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120.". Eur. J. Immunol. 25 (5): 1306–11. PMID 7539755.
- Howcroft TK, Palmer LA, Brown J, et al. (1995). "HIV Tat represses transcription through Sp1-like elements in the basal promoter.". Immunity 3 (1): 127–38. PMID 7621073.
- Chen YH, Böck G, Vornhagen R, et al. (1994). "HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1 expression on H9 and U937 cells.". Int. Arch. Allergy Immunol. 104 (3): 227–31. PMID 7913356.
- Chen YH, Böck G, Vornhagen R, et al. (1994). "HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41.". Mol. Immunol. 31 (13): 977–82. PMID 8084338.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
- Howcroft TK, Strebel K, Martin MA, Singer DS (1993). "Repression of MHC class I gene promoter activity by two-exon Tat of HIV.". Science 260 (5112): 1320–2. PMID 8493575.
- Gasparini P, Borgato L, Piperno A, et al. (1993). "Linkage analysis of 6p21 polymorphic markers and the hereditary hemochromatosis: localization of the gene centromeric to HLA-F.". Hum. Mol. Genet. 2 (5): 571–6. PMID 8518796.
- Schwartz O, Maréchal V, Le Gall S, et al. (1996). "Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein.". Nat. Med. 2 (3): 338–42. PMID 8612235.
- Alexander-Miller MA, Parker KC, Tsukui T, et al. (1997). "Molecular analysis of presentation by HLA-A2.1 of a promiscuously binding V3 loop peptide from the HIV-envelope protein to human cytotoxic T lymphocytes.". Int. Immunol. 8 (5): 641–9. PMID 8671651.
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Major histocompatibility complex/
Human leukocyte antigen |
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HLA-DM ( α, β) • HLA-DO ( α, β) • HLA-DP ( α1, β1) • HLA-DQ ( α1, α2, β1, β2, β3) • HLA-DR ( α, β1, β3, β4, β5)
Minor histocompatibility antigen
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