Noble French Roman Catholic family that played a major role in French politics during the
Reformation. Claude de Lorraine (1496 – 1550) was created the 1st duke de Guise in 1527 for his service to
Francis I in the defense of France. Claude's sons François, 2nd duke de
Guise, and Charles, cardinal de Lorraine (1524 – 1574), gained great power during the reign of
Francis II. Supported by Spain and the papacy, their persecution of the
Huguenots led to the unsuccessful Amboise Conspiracy (1560), an attempted assassination of the leaders of the Guise party and transfer of power to the house of
Bourbon. The Guise-led massacre of a Huguenot congregation at Vassy precipitated the Wars of
Religion, in which Henri I, 3rd duke de
Guise, was a prominent leader. Charles de Lorraine, 4th duke de Guise (1571 – 1640), lived through the rapid decline of the family's power. Henri II, 5th duke de
Guise, tried unsuccessfully to revive the family's power; the direct line expired with the death of his grand-nephew in 1675.
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