HPC may may refer to:
- Handheld PC
- Hasty Pudding Cipher
- Health Professions Council
- Hemangiopericytoma
- Hematopoietic progenitor cell
- High-performance computing
- Hmar Peoples Convention, a separatist political party in the Indian state of Mizoram
- HousePriceCrash
- Hydrometeorological Prediction Center
- Hydroxypropyl cellulose
- High-performance computing
- Windows HPC Server 2008, an operating system for high-performance computing by Microsoft
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