HPL could refer to:
- H. P. Lovecraft
- Hamilton Public Libraries, Hamilton, New Zealand
- Hamilton Public Library, Ontario, Canada
- Harry Potter Lexicon
- Hartlepool railway station, England; National Rail station code HPL.
- Hebrew Programming Language
- Heliportugal; ICAO airline code HPL.
- Hewlett-Packard Language, the RPN based computer programming language used in early Hewlett-Packard desktop calculators, such as the HP9825A
- High Pressure Laminate, a type of durable composite material (for example, Formica (plastic), Arborite or Wilsonart).
- Hindustan Prefab Limited, a project of the Ministry of Housing and Urban Poverty Alleviation (India)
- Hotel Properties Ltd, Singapore
- Houston Public Library, Texas, United States
- Human pancreatic lipase
- Human placental lactogen
- HPL (1890-1991), a biography of H. P. Lovecraft by Roland Charles Wagner
- A product manufactured by Seohan Chemical
- Hendi Penyet Lesley, Wet and Wild
- High Performance Linpack
- Hutchison Whampoa Property, formerly Hutchison Property Limited, a property developer in Hong Kong
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