HSD may stand for:
- Hybrid Synergy Drive
- Homeland Security Department
- Hamstead railway station, England; National Rail station code HSD.
- Hardanger Sunnhordlandske Dampskipsselskap, a Norwegian transport coorperation.
- High Speed Data
- High speed diesel fuel, for diesel engines
- Hypertonic Saline-Dextran, an intravenous liquid administered in emergency resuscitation from hypovolemic shock.
- Hypoactive sexual desire, refers to a low level of sexual desire. (see Inhibited sexual desire)
HSD may also mean:
- Tukey HSD, a multiple comparisons method in statistics
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