hyaluronidase

n.
An enzyme that catalyzes the breakdown of hyaluronic acid in the body, thereby increasing tissue permeability to fluids. Also called spreading factor.

Any one of a family of enzymes, also known as hyaluronate lyases or spreading factors, produced by mammals, reptiles, insects, and bacteria, which catalyze the breakdown of hyaluronic acid. Some hyaluronidases also attack other similar polysaccharides. Since all liquefy the polysaccharide gel which fills the tissue spaces, they effectively accelerate diffusion so that injected, dissolved, or particulate matter (bacteria, viruses, toxins, or pigments) can diffuse through a larger volume of tissue. See also Hyaluronic acid.

The biological importance of the enzyme depends upon its source. That found in the culture filtrates of many strains of virulent bacteria permits the microorganisms to gain access to a larger volume of the host's tissue and, hence, to additional nutriment. That found in the venom of certain snakes and bees permits the toxin to produce more extensive damage to the victim. See also Enzyme.

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An enzyme which contributes to the break down of hyaluronic acid, a constituent of connective tissue. Hyaluronidase occurs naturally in many tissues. Preparations are injected into the skin of patients undergoing liposuction. The enzyme assists in breaking down the connective tissue so that the fat can be sucked out more easily. Hyaluronidase has also been used successfully to treat bruises.

(hī'-əl-yōōr-on'ədās)
n

An enzyme that produces hydrolysis of hyaluronic acid, the cementing substance of the tissues. Produced by certain pathogenic bacteria and also formed by sperm.

Brand names: Amphadase™Hydase™Vitrase®Wydase®

Drug Forms:
• Hyaluronidase Solution for injection (below)
• Hyaluronidase Solution for injection
• Hyaluronidase ovine injection
• Hyaluronidase bovine injection

Español:
• Hialuronidasa , Solución para inyección
• Hialuronidasa (bovina), Solución para inyección
• Inyección de hialuronidasa ovina

Hyaluronidase Solution for injection

What is this medicine?

HYALURONIDASE is a natural protein. It is used to improve the effects of other injectable medicines given with this medicine.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•allergy to bee stings or other insects
•infection in the area where injection is planned
•an unusual or allergic reaction to hyaluronidase, sheep proteins, beef proteins, thimerosal, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

This medicine is for injection under the skin or into a muscle. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as newborn for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

•ACTH
•antihistamines for allergy or cold
•aspirin and aspirin-like medicines
•benzodiazepines for anxiety or sleep
•female hormones like estrogens
•furosemide
•phenytoin
•steroid medicines like prednisone or cortisone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine. Visit your doctor for check-ups as directed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•breathing problems
•chest pain
•chills
•fast, irregular heartbeat
•feeling faint or lightheaded, falls
•nausea or vomiting
•swelling at site where injected

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•inflammation, redness or pain at site where injected

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Last updated: 12/27/2004 10:25:00 AM

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

An enzyme found in the testes, semen, and other tissues. Preparations of hyaluronidase have been used successfully to treat bruises.

An enzyme that catalyzes the hydrolysis of hyaluronic acid, the ‘cement material’ of connective tissues; it is found in leeches, snake and spider venom, in testes, and is produced by various pathogenic bacteria, enabling them to spread through tissue. A preparation from mammalian testes is used to promote absorption and diffusion of solutions injected subcutaneously. When hyaluronidase is mixed with fluids administered subcutaneously, absorption is more rapid and less uncomfortable. Hyaluronidase should not be given in areas where there is infection. Since it hastens absorption, it must be given with caution when administered with toxic drugs, as the toxic reaction can occur very rapidly.

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