iC3b is the proteolyticly inactive product of the complement cleavage fragment C3b[1] that still opsonizes microbes, but cannot associate with factor B. Thus preventing amplification of the complement cascade or activation through the alternative pathway.
References
- ^ Robbins Basic Pathology 8th ed 2007. R Cotran, S Robbins, V Kumar, J Perkins. W.B. Saunders Company.
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