A pyrimidine analog that prevents replication of DNA viruses; used topically in infection by herpesviruses.
Idoxuridine
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Idoxuridine
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| Systematic (IUPAC) name | |
| 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione | |
| Identifiers | |
| CAS number | 54-42-2 |
| ATC code | D06BB01 J05, S01 |
| PubChem | 5905 |
| DrugBank | APRD00504 |
| Chemical data | |
| Formula | C9H11IN2O5 |
| Mol. mass | 354.099 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | intravenously |
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Idoxuridine is an anti-herpesvirus antiviral drug.
It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing.
External links
- Seth A, Misra A, Umrigar D (2004). "Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications.". Pharm Dev Technol 9 (3): 277–89. doi:. PMID 15458233.
- Otto S. "Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine).". J Intraven Nurs 21 (6): 335–7. PMID 10392098.
- Fauth E, Zankl H (1999). "Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting.". Mutat Res 440 (2): 147–56. PMID 10209337.
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 | Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Idoxuridine". Read more |
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Mentioned in
- antiviral
- Why is it difficult to treat viral infections with medications? (anatomy)
- Smallpox (infectious diseases/epidemiology)
- Genital Herpes: Treatment
