IGFBP6

edit

Insulin-like growth factor binding protein 6
PDB rendering based on 2jm2.
Available structures
2jm2
Identifiers
Symbols	IGFBP6; IBP6
External IDs	OMIM: 146735 MGI: 96441 HomoloGene: 1641
Gene ontology Molecular function • insulin-like growth factor binding Cellular component • extracellular region • extracellular space Biological process • regulation of cell growth • signal transduction • negative regulation of cell proliferation
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3489	16012
Ensembl	ENSG00000167779	ENSMUSG00000023046
UniProt	P24592	Q91X24
RefSeq	NM_002178 (mRNA)	NM_008344 (mRNA)
	NP_002169 (protein)	NP_032370 (protein)
Location	Chr 12: 51.78 - 51.78 Mb	Chr 15: 101.97 - 101.98 Mb
PubMed search	[1]	[2]

Insulin-like growth factor-binding protein 6 is a protein that in humans is encoded by the IGFBP6 gene.^[1][2][3]

References

1. ^ Kiefer MC, Ioh RS, Bauer DM, Zapf J (May 1991). "Molecular cloning of a new human insulin-like growth factor binding protein". Biochem Biophys Res Commun 176 (1): 219-25. PMID 1850258. 
2. ^ Ehrenborg E, Zazzi H, Lagercrantz S, Granqvist M, Hillerbrand U, Allander SV, Larsson C, Luthman H (May 1999). "Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene". Mamm Genome 10 (4): 376-80. PMID 10087296. 
3. ^ "Entrez Gene: IGFBP6 insulin-like growth factor binding protein 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3489. 

Further reading

• Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish.". Int. Rev. Cytol. 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. PMID 15797461. 
• Zapf J, Kiefer M, Merryweather J, et al. (1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia.". J. Biol. Chem. 265 (25): 14892–8. PMID 1697583. 
• Kiefer MC, Masiarz FR, Bauer DM, Zapf J (1991). "Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum.". J. Biol. Chem. 266 (14): 9043–9. PMID 1709161. 
• Shimasaki S, Gao L, Shimonaka M, Ling N (1991). "Isolation and molecular cloning of insulin-like growth factor-binding protein-6.". Mol. Endocrinol. 5 (7): 938–48. doi:10.1210/mend-5-7-938. PMID 1719383. 
• Andress DL, Birnbaum RS (1991). "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells.". Biochem. Biophys. Res. Commun. 176 (1): 213–8. doi:10.1016/0006-291X(91)90911-P. PMID 1850257. 
• Martin JL, Willetts KE, Baxter RC (1990). "Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts.". J. Biol. Chem. 265 (7): 4124–30. PMID 2154495. 
• Roghani M, Hossenlopp P, Lepage P, et al. (1989). "Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II.". FEBS Lett. 255 (2): 253–8. doi:10.1016/0014-5793(89)81101-9. PMID 2551732. 
• Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland.". Mol. Cell. Endocrinol. 97 (1-2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544. 
• Kato M, Ishizaki A, Hellman U, et al. (1995). "A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-beta and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner.". J. Biol. Chem. 270 (21): 12373–9. doi:10.1074/jbc.270.21.12373. PMID 7539002. 
• Delhanty PJ, Hill DJ, Shimasaki S, Han VK (1993). "Insulin-like growth factor binding protein-4, -5 and -6 mRNAs in the human fetus: localization to sites of growth and differentiation?". Growth Regul. 3 (1): 8–11. PMID 7683540. 
• Bach LA, Hsieh S, Sakano K, et al. (1993). "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6.". J. Biol. Chem. 268 (13): 9246–54. PMID 7683646. 
• Wegmann BR, Schöneberger HJ, Kiefer PE, et al. (1993). "Molecular cloning of IGFBP-5 from SCLC cell lines and expression of IGFBP-4, IGFBP-5 and IGFBP-6 in lung cancer cell lines and primary tumours.". Eur. J. Cancer 29A (11): 1578–84. doi:10.1016/0959-8049(93)90298-T. PMID 7692907. 
• Neumann GM, Marinaro JA, Bach LA (1998). "Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6.". Biochemistry 37 (18): 6572–85. doi:10.1021/bi972894e. PMID 9572875. 
• Neumann GM, Bach LA (1999). "The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry.". J. Biol. Chem. 274 (21): 14587–94. doi:10.1074/jbc.274.21.14587. PMID 10329650. 
• Wong MS, Fong CC, Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins.". Biochim. Biophys. Acta 1432 (2): 293–301. PMID 10407151. 
• Yu H, Mistry J, Nicar MJ, et al. (1999). "Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation.". J. Clin. Lab. Anal. 13 (4): 166–72. doi:10.1002/(SICI)1098-2825(1999)13:4<166::AID-JCLA5>3.0.CO;2-X. PMID 10414596. 
• Dailly YP, Zhou Y, Linkhart TA, et al. (2001). "Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element.". Biochim. Biophys. Acta 1518 (1-2): 145–51. PMID 11267670. 
• Weinzimer SA, Gibson TB, Collett-Solberg PF, et al. (2001). "Transferrin is an insulin-like growth factor-binding protein-3 binding protein.". J. Clin. Endocrinol. Metab. 86 (4): 1806–13. doi:10.1210/jc.86.4.1806. PMID 11297622. 

v • d • e PDB Gallery 2jm2: Structure of the N-terminal subdomain of insulin-like growth factor (IGF) binding protein-6 and its interactions with IGFs

This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it. v • d • e

v • d • e Proteins: carrier proteins Fatty acid FABP1 · FABP2 · FABP3 · FABP4 · FABP5 · FABP6 · FABP7 Hormone Follistatin · Growth hormone binding protein · Insulin-like growth factor binding protein (IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6, IGFBP7) · Neurophysins (Neurophysin I, II) Sex hormone binding globulin/Androgen binding protein · Transcortin · Thyroxine-binding globulin · Transthyretin Metal/element calcium (Calcium-binding protein, Calmodulin-binding proteins) · copper (Ceruloplasmin) · iron (Iron-binding proteins, Transferrin receptor) Vitamin Retinol binding protein (4) · Transcobalamin Other Acyl carrier protein · Adaptor protein · Cholesterylester transfer protein · F-box protein · GTP-binding protein · Latent TGF-beta binding protein · Light-harvesting complex · Membrane transport protein

This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)