IL2 or IL-2 may be:
- Ilyushin Il-2 Shturmovik, a World War II era Soviet ground attack aircraft
- IL-2 Sturmovik (video game), game featuring the Ilyushin Il-2 aircraft
- Interleukin 2, a cytokine glycoprotein that stimulates the growth of T cell lymphocytes and provides other biochemical signalling to the immune system
- Illinois' 2nd congressional district
- Illinois Route 2
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