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| Interleukin 17A | ||||||||||||||
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| Identifiers | ||||||||||||||
| Symbols | IL17A; CTLA8; IL-17; IL-17A; IL17 | |||||||||||||
| External IDs | OMIM: 603149 MGI: 107364 HomoloGene: 1651 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| More reference expression data | ||||||||||||||
| Orthologs | ||||||||||||||
| Species | Human | Mouse | ||||||||||||
| Entrez | 3605 | 16171 | ||||||||||||
| Ensembl | ENSG00000112115 | ENSMUSG00000025929 | ||||||||||||
| UniProt | Q16552 | Q544E6 | ||||||||||||
| RefSeq | NM_002190 (mRNA) | NM_010552 (mRNA) | ||||||||||||
| NP_002181 (protein) | NP_034682 (protein) | |||||||||||||
| Location | Chr 6: 52.16 - 52.16 Mb |
Chr 1: 20.72 - 20.72 Mb |
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| PubMed search | [1] | [2] | ||||||||||||
Interleukin-17A is a protein that in humans is encoded by the IL17A gene.[1][2]
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.[2]
See also
References
- ^ Rouvier E, Luciani MF, Mattei MG, Denizot F, Golstein P (Jul 1993). "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene". J Immunol 150 (12): 5445-56. PMID 8390535.
- ^ a b "Entrez Gene: IL17A interleukin 17A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3605.
Further reading
- Gaffen SL (2005). "Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis.". Arthritis Res. Ther. 6 (6): 240–7. doi:. PMID 15535837.
- Lubberts E, Koenders MI, van den Berg WB (2006). "The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models.". Arthritis Res. Ther. 7 (1): 29–37. doi:. PMID 15642151.
- Yao Z, Painter SL, Fanslow WC, et al. (1996). "Human IL-17: a novel cytokine derived from T cells.". J. Immunol. 155 (12): 5483–6. PMID 7499828.
- Fossiez F, Djossou O, Chomarat P, et al. (1996). "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.". J. Exp. Med. 183 (6): 2593–603. doi:. PMID 8676080.
- Yao Z, Spriggs MK, Derry JM, et al. (1998). "Molecular characterization of the human interleukin (IL)-17 receptor.". Cytokine 9 (11): 794–800. doi:. PMID 9367539.
- Murphy KP, Gagne P, Pazmany C, Moody MD (1998). "Expression of human interleukin-17 in Pichia pastoris: purification and characterization.". Protein Expr. Purif. 12 (2): 208–14. doi:. PMID 9518462.
- Teunissen MB, Koomen CW, de Waal Malefyt R, et al. (1998). "Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.". J. Invest. Dermatol. 111 (4): 645–9. doi:. PMID 9764847.
- Shalom-Barak T, Quach J, Lotz M (1998). "Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB.". J. Biol. Chem. 273 (42): 27467–73. doi:. PMID 9765276.
- Shin HC, Benbernou N, Fekkar H, et al. (1999). "Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway.". Cytokine 10 (11): 841–50. doi:. PMID 9878122.
- Laan M, Cui ZH, Hoshino H, et al. (1999). "Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways.". J. Immunol. 162 (4): 2347–52. PMID 9973514.
- Kotake S, Udagawa N, Takahashi N, et al. (1999). "IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.". J. Clin. Invest. 103 (9): 1345–52. doi:. PMID 10225978.
- Shin HC, Benbernou N, Esnault S, Guenounou M (1999). "Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway.". Cytokine 11 (4): 257–66. doi:. PMID 10328864.
- Andoh A, Takaya H, Makino J, et al. (2001). "Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells.". Clin. Exp. Immunol. 125 (1): 56–63. doi:. PMID 11472426.
- Laan M, Palmberg L, Larsson K, Lindén A (2002). "Free, soluble interleukin-17 protein during severe inflammation in human airways.". Eur. Respir. J. 19 (3): 534–7. doi:. PMID 11936535.
- Andoh A, Fujino S, Bamba S, et al. (2002). "IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts.". J. Immunol. 169 (4): 1683–7. PMID 12165487.
- Andoh A, Shimada M, Bamba S, et al. (2002). "Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts.". Biochim. Biophys. Acta 1591 (1-3): 69–74. doi:. PMID 12183057.
- Hsieh HG, Loong CC, Lin CY (2003). "Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells.". Cytokine 19 (4): 159–74. doi:. PMID 12297109.
- Aggarwal S, Ghilardi N, Xie MH, et al. (2003). "Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.". J. Biol. Chem. 278 (3): 1910–4. doi:. PMID 12417590.
- Maertzdorf J, Osterhaus AD, Verjans GM (2003). "IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts.". J. Immunol. 169 (10): 5897–903. PMID 12421973.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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