Immunomodulator

An immunomodulator is a substance (e. g. a drug) which has an effect on the immune system. There are two types of such substances:

• Immunosuppressants
• Immunostimulants

External links

• MeSH Immunomodulators

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v • d • e Major drug groups Gastrointestinal tract/metabolism (A) stomach acid (Antacids, H2 antagonists, Proton pump inhibitors) • Antiemetics • Laxatives • Antidiarrhoeals/Antipropulsives • Anti-obesity drugs • Anti-diabetics • Vitamins • Dietary minerals Blood and blood forming organs (B) Antithrombotics (Antiplatelets, Anticoagulants, Thrombolytics/fibrinolytics) • Antihemorrhagics (Platelets, Coagulants, Antifibrinolytics) Cardiovascular system (C) cardiac therapy/antianginals (Cardiac glycosides, Antiarrhythmics, Cardiac stimulants) Antihypertensives • Diuretics • Vasodilators • Beta blockers • Calcium channel blockers • renin-angiotensin system (ACE inhibitors, Angiotensin II receptor antagonists, Renin inhibitors) Antihyperlipidemics (Statins, Fibrates, Bile acid sequestrants) Skin (D) Emollients • Cicatrizants • Antipruritics • Antipsoriatics • Medicated dressings Reproductive system (G) Hormonal contraception • Fertility agents • SERMs • Sex hormones Endocrine system (H) Hypothalamic-pituitary hormones • Corticosteroids (Glucocorticoids, Mineralocorticoids) • Sex hormones • Thyroid hormones/Antithyroid agents Infections and infestations (J, P, QI) Antibiotics • Antimycobacterials (Tuberculosis treatment, Leprostatic agents) • Antifungals • Antivirals • Vaccines • Antiparasitics (Antiprotozoals, Anthelmintics) • Ectoparasiticide Malignant disease (L01-L02) Anticancer agents (Antimetabolites, Alkylating, Spindle poisons, Antineoplastic, Topoisomerase inhibitors) Immune disease (L03-L04) Immunomodulators (Immunostimulants, Immunosuppressants) Muscles, bones, and joints (M) Anabolic steroids • Anti-inflammatories (NSAIDs) • Antirheumatics • Corticosteroids • Muscle relaxants • Bisphosphonates Brain and nervous system (N) Anesthetics (General, Local) • Analgesics • Antimigraines • Anticonvulsants/Mood stabilizers (Lithium pharmacology) • Antiparkinson drugs Psycholeptics (Anxiolytics, Antipsychotics, Hypnotics/Sedatives) • Psychoanaleptics (Antidepressants, Stimulants) Respiratory system (R) Decongestants • Bronchodilators • Cough medicines • H1 antagonists Sensory organs (S) Ophthalmologicals • Otologicals Other ATC (V) Antidotes • Contrast media • Radiopharmaceuticals • Dressings

v • d • e Immunomodulators: Immunostimulants (L03) Endogenous Cytokines Colony-stimulating factors G-CSF (Filgrastim/Pegfilgrastim, Lenograstim) · GM-CSF (Molgramostim, Sargramostim) · SCF (Ancestim) Interferons alpha: Interferon alpha natural · Interferon alfa-2a/Peginterferon alfa-2a · Interferon alfa-2b/Peginterferon alfa-2b · Interferon alfa-n1 · Interferon alfacon-1 beta: Interferon beta natural · Interferon beta-1a · Interferon beta-1b Interferon gamma Interleukins Aldesleukin · Oprelvekin Other protein/peptide Pegademase · Immunocyanin · Tasonermin · Prolactin · Growth hormone Other Female sex steroids · Vitamin D · Poly ICLC · Histamine dihydrochloride Exogenous BCG vaccine · Glatiramer acetate · Lentinan · Melanoma vaccine · Pidotimod · Plerixafor · Poly I:C · Roquinimex · Thymopentin

v • d • e Immunomodulators: Immunosuppressive drugs / Immunosuppressants (L04) Intracellular (signal initiation) Antimetabolites purine synthesis inhibitor: Azathioprine · Mycophenolic acid pyrimidine synthesis inhibitor: Leflunomide · Teriflunomide antifolate: Methotrexate Macrolides/ other IL-2 inhibitors FKBP/Cyclophilin/Calcineurin: Tacrolimus · Ciclosporin · Pimecrolimus Abetimus · Gusperimus TNF-α inhibitor Thalidomide · Lenalidomide Intracellular (signal reception) IL-1 receptor antagonists Anakinra mTOR Sirolimus · Deforolimus · Everolimus · Temsirolimus · Zotarolimus Extracellular Antibodies Monoclonal Serum target (noncellular) Complement component 5 (Eculizumab) · TNFs (Infliximab, Adalimumab, Certolizumab pegol, Afelimomab, Golimumab) · Interleukin 5 (Mepolizumab) · Immunoglobulin E (Omalizumab)  · BAYX (Nerelimomab) Interferon (Faralimomab) IL-6 (Elsilimomab) IL-12 and IL-13 (Ustekinumab) Cellular target CD3 (Muromonab-CD3, Otelixizumab, Teplizumab, Visilizumab) · CD4 (Clenoliximab, Keliximab, Zanolimumab) · CD11a (Efalizumab) · CD18 (Erlizumab) · CD20 (Afutuzumab, Ocrelizumab, Pascolizumab) · CD23 (Lumiliximab) · CD40 (Teneliximab, Toralizumab) · CD62L/L-selectin (Aselizumab) · CD80 (Galiximab) · CD147/Basigin (Gavilimomab, Ziralimumab) · CD154 (Ruplizumab) BLyS (Belimumab)  · CTLA-4 (Ipilimumab, Tremelimumab) · CAT (Bertilimumab, Lerdelimumab, Metelimumab) · Integrin (Natalizumab) · Interleukin-6 receptor (Tocilizumab) · LFA-1 (Odulimomab) IL-2 receptor/CD25 (Basiliximab, Daclizumab, Inolimomab) T-lymphocyte (Zolimomab aritox) Unsorted Atlizumab, Atorolimumab, Cedelizumab, Dorlimomab aritox, Dorlixizumab, Fontolizumab, Gantenerumab, Gomiliximab, Lebrilizumab, Maslimomab, Morolimumab, Pexelizumab, Reslizumab, Rovelizumab, Siplizumab, Talizumab, Telimomab aritox, Vapaliximab, Vepalimomab Polyclonal Anti-thymocyte globulin · Anti-lymphocyte globulin -cept (Fusion protein) CTLA-4 (Abatacept, Belatacept) · Aflibercept · Alefacept · Rilonacept · TNF inhibitor (Etanercept)

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