Intrinsically, considered alone. For example, In and of itself the plan might work, but I doubt that it will be approved. It is also put simply as in itself, as in This account may be true in itself. [First half of 1600s]

The American Heritage® Dictionary of Idioms by Christine Ammer. Copyright © 1997 by The Christine Ammer 1992 Trust. Published by Houghton Mifflin Company. All rights reserved.