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It has been suggested that InSilico modeling be merged into this article or section. (Discuss) |
In silico is an expression used to mean "performed on computer or via computer simulation." The phrase is coined in analogy to the Latin phrases in vivo and in vitro which are commonly used in biology (see also systems biology) and refer to experiments done in living organisms and outside of living organisms, respectively. Contrary to widespread belief, in silico does not mean anything in Latin. The proper Latin phrase would likely be in simulacro to describe experiments done on the likeness (simulacrum) or model of a phenomenon.
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History
The expression in silico was first used in public in 1989 in the workshop "Cellular Automata: Theory and Applications" in Los Alamos, New Mexico. Pedro Miramontes, a mathematician from National Autonomous University of Mexico (UNAM) presented the report "DNA and RNA Physicochemical Constraints, Cellular Automata and Molecular Evolution". In his talk, Miramontes used the term "in silico" to characterize biological experiments carried out entirely in a computer. The work was later presented by Miramontes as his PhD dissertation.[1]
In silico has been used in white papers written to support the creation of bacterial genome programs by the Commission of the European Community. The first referenced paper where "in silico" appears was written by a French team in 1991.[2] The first referenced book chapter where "in silico" appears was written by Hans B. Sieburg in 1990 and presented during a Summer School on Complex Systems at the Santa Fe Institute.[3]
In silico versus in silicio
"In silico" was briefly challenged by "in silicio," which is correct Latin for "in silicon" (the Latin term for silicon, silicium, was created at the beginning of the 19th century by Berzelius. Silex is also a correct latin word).[citation needed] But the phrase "in silice" means "in flint" in Latin. "In silico" was perceived as catchier, possibly through similarity to the words "vivo" and "vitro"[citation needed] "In silico" is now almost universal; it even occurs in a journal title (In Silico Biology: http://www.bioinfo.de/isb/).
"In silico" is reasonable from the viewpoint of (ancient) Greek case endings; the "-on" ending for certain elements is from Greek. In Greek, "silicon" would take the form "silico" in such a phrase. Latin typically uses the correct Greek forms for Greek words when they are used in Latin.
The phrase "in silico" originally applied only to computer simulations that modeled natural or laboratory processes (in all the natural sciences), and did not refer to calculations done by computer generically.
See also
- List of Latin phrases
- ex vivo
- in situ
- in utero
- in vitro
- in vivo
- in papyro
- In silico molecular design programs
References
- ^ Miramontes P. Un modelo de autómata celular para la evolución de los ácidos nucleicos [A cellular automaton model for the evolution of nucleic acids]. Tesis de doctorado en matemáticas. UNAM. 1992.
- ^ Danchin A, Medigue C, Gascuel O, Soldano H, Henaut A. From data banks to data bases. Res Microbiol. 1991 Sep-Oct;142(7-8):913-6. PMID 1784830.
- ^ Sieburg, H.B. (1990). Physiological Studies in silico. Studies in the Sciences of Complexity 12, 321-342.
External links
- World Wide Words: In silico
- CADASTER Seventh Framework Programme project aimed to develop in silico computational methods to minimize experimental tests for REACH Registration, Evaluation, Authorisation and Restriction of Chemicals
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