Inositol trisphosphate receptor: Information from Answers.com

inositol 1,4,5-trisphosphate receptor, type 1
Identifiers
Symbol	ITPR1
Entrez	3708
HUGO	6180
OMIM	147265
RefSeq	NM_002222
UniProt	Q14643
Other data
Locus	Chr. 3 p26.1

inositol 1,4,5-trisphosphate receptor, type 2
Identifiers
Symbol	ITPR2
Entrez	3709
HUGO	6181
OMIM	600144
RefSeq	NM_002223
UniProt	Q14571
Other data
Locus	Chr. 12 p11.23

inositol 1,4,5-trisphosphate receptor, type 3
Identifiers
Symbol	ITPR3
Entrez	3710
HUGO	6182
OMIM	147267
RefSeq	NM_002224
UniProt	Q14573
Other data
Locus	Chr. 6 p21.31

Inositol trisphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca²⁺ channel activated by inositol trisphosphate (IP3). The IP3 receptor was first purified from rat cerebellum^[1].

1 Distribution
2 Structure
3 See also
4 References
5 External links

Distribution

It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the IP3Rs are found in the cell integrated into the endoplasmic reticulum.

Structure

The IP3R complex is formed of four 313 kDa subunits. In amphibians, fish and mammals there are 3 paralogs and these can form homo- or hetero-oligomers. IP3R-1 is the most widely expressed of these three and is found in all tissue types and all developmental stages of life. It is additionally the means for further IP3 receptor diversity in that it has as many as four splice sites with as many as 9 different optional exons or exon variants. Combinations of these can be introduced into a given transcript in order to modulate its pharmacological activity.

References

^ Inositol trisphosphate receptor Ca2+ release chann...[Physiol Rev. 2007] - PubMed Result

External links

MeSH Inositol+Trisphosphate+Receptor

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

v • d • e Cell signaling: lipid signaling

Cell membrane	LPA · Lysophospholipid receptor · S1P · PIP₂ · DAG

Cytosol	Phospholipase · IP₃

Sarcoplasmic reticulum	IP₃ receptor

Gq alpha subunit	Phosphoinositide phospholipase C

Membrane transport protein: ion channels

Ca²⁺: Calcium channel

Voltage-gated	L-type/Ca_vα (1.1, 1.2, 1.3, 1.4) · N-type/Ca_vα2.2 · P-type/Ca_vα(2.1) · Q-type/Ca_vα2.1 · R-type/Ca_vα2.3 · T-type/Ca_vα(3.1, 3.2, 3.3) α₂δ-subunits (1, 2) · β-subunits (β1, β2, β3, β4) · γ-subunits (γ1, γ2, γ3, γ4) Cation channels of sperm (1, 2, 3, 4) · Two-pore channel (1, 2)

Ligand-gated	Inositol trisphosphate receptor (1, 2, 3) · Ryanodine receptor (1, 2, 3)

Na⁺: Sodium channel

Voltage-gated	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) · Na_vβ (1, 2, 3, 4)

Constitutively active	Epithelial sodium channel (α, β, γ, δ)

K⁺: Potassium channel

Voltage-gated	K_vα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.10) · (2.1, 2.2) · (3.1, 3.2, 3.3, 3.4) · (4.1, 4.2, 4.3) · (5.1) · (6.1, 6.2, 6.3, 6.4) K_vα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) · (8.1, 8.2) · (9.1, 9.2, 9.3) · (10.1, 10.2) · (11.1/hERG, 11.2, 11.3) · (12.1, 12.2, 12.3) K_vβ (1, 2, 3) · KCNIP (1, 2, 3, 4) · minK/ISK · minK/ISK-like · MiRP (1, 2, 3) · Shaker gene

Calcium-activated	BK channel (α1, β1, β2, β3, β4) · SK channel (SK1, SK2, SK3, SK4) · K_Ca (1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1)

Inward-rectifier	K_ir (1.1, 2.1, 2.2, 2.3, 2.4) · GIRK/K_ir (3.1, 3.2, 3.3, 3.4) · K_ir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)

Tandem pore domain	K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)

Other


M⁺: TRP cation channel	TRPA (1) · TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) · TRPM (1, 2, 3, 4, 5, 6, 7, 8) · TRPML (1, 2, 3) · TRPP (1, 2) · TRPV (1, 2, 3, 4, 5, 6)

Cl^-: Chloride channel	ANO1 · Bestrophin (1, 2) · CFTR · CLCA (1, 2, 3, 4) · CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) · CLIC (1, 2, 3, 4, 5, 6, L1) · CLNS (1A, 1B)

Cyclic nucleotide-gated (FC)	α (1, 2, 3, 4) · β (1, 2, 3) · HCN (1, 2, 3, 4)

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) · Voltage-dependent anion channel (1, 2, 3) · General bacterial porin family

General	Ligand-gated ion channel · Voltage-gated ion channel · Stretch-activated ion channel

	see also disorders

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Inositol trisphosphate receptor

Contents

Distribution

Structure

See also

References

External links