Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells.
IRS-1, for example, is an IRS protein which contains a PTB [disambiguation needed]-domain. In addition, the insulin receptor contains a NPXpY domain. The PTB-domain binds the NPXpY domain. Thus, the insulin receptor binds IRS.
Genes
- IRS1 (see also Insulin receptor substrate 1)
- IRS2 (see also Insulin receptor substrate 2)
- IRS3L
- IRS4
References
- van der Geer P, Wiley S, Pawson T (1999). "Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site". Oncogene 18 (20): 3071–5. doi:. PMID 10340378.
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