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Intercalation may refer to:
- The insertion of a leap day, week or month into some calendar years to make the calendar follow the seasons.
- Chemistry, where intercalation is the insertion of a molecule (or group) between two other molecules (or groups). For example, 2,4 dichlorophenoxyacetic acid or 2-(2,4 dichlorophenoxy-)propionic acid intercalates between layers of clays.
- In literature, a technique used to insert one narrative inside another, implying simultaneity. It is also called a "hybrid story" and is used often in the Gospel of Mark, for example in the narrative of the daughter of Jairus.
- University administration, where intercalation is the period when a student is officially suspended from studying for an academic degree.
- By very broad metaphor, intercalation is also used to describe the insertion of a (usually pithy) comment about an email or Usenet message into some structural part (like a signature) where message content would not normally go.
- In biology:
- Intercalation can refer to how certain drugs and mutagen bind to DNA. This type of intercalation was discovered by Leonard Lerman.
- Intercalated duct of exocrine glands
- Intercalated disc of cardiac muscle
- Intercalated cells of the collecting duct
- Intercalated cells of the amygdala
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