Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).[2]
The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.[3]
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Transmembrane receptors: immune receptors |
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| Cytokine receptor |
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Interleukins ( 2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27)
CSF receptors (EPO, GM-CSF, G-CSF)
GH · prolactin · Oncostatin M · Leukemia inhibitory factor
common subunits ( Common gamma chain, common beta chain, gp130)
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Other
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