Interleukin-25 (IL-25) is a cytokine that belongs to the IL-17 cytokine family and is secreted by type 2 helper T cells (Th2) and mast cells.[1] It is also known as IL-17E.[2] IL-25 induces the production of other cytokines, including IL-4, IL-5 and IL-13 in multiple tissues, which stimulate the expansion of eosinophils. This cytokine is an important molecule controlling immunity of the gut[3] and has been implicated in chronic inflammation associated with the gastrointestinal tract. Further, the IL-25 gene has been identified in a chromosomal region associated with autoimmune diseases of the gut such as inflammatory bowel disease (IBD), although no direct evidence suggests that IL-25 plays any role in this disease.[4]
References
- ^ Ikeda K, Nakajima H, Suzuki K, Kagami S, Hirose K, Suto A, Saito Y, Iwamoto I (May 2003). "Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation". Blood 101 (9): 3594–6. doi:10.1182/blood-2002-09-2817. PMID 12511410.
- ^ The HGNC site for IL-25
- ^ Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, Miller HR, Cua DJ, Goldschmidt M, Hunter CA, Kastelein RA, Artis D (April 2006). "Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract". J. Exp. Med. 203 (4): 843–9. doi:10.1084/jem.20051496. PMID 16606667.
- ^ Büning C, Genschel J, Weltrich R, Lochs H, Schmidt H (October 2003). "The interleukin-25 gene located in the inflammatory bowel disease (IBD) 4 region: no association with inflammatory bowel disease". Eur. J. Immunogenet. 30 (5): 329–33. PMID 14641539.
Further reading
- Fallon PG, Ballantyne SJ, Mangan NE, Barlow JL, Dasvarma A, Hewett DR, McIlgorm A, Jolin HE, McKenzie AN (April 2006). "Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion". J. Exp. Med. 203 (4): 1105–16. doi:10.1084/jem.20051615. PMID 16606668.
|
Cell signaling: cytokines |
|
| By family |
|
|
|
IL-1 superfamily
|
|
|
|
|
|
|
|
IL-10 family
|
|
|
|
|
|
|
|
|
|
|
|
IL-12 family
|
|
|
|
Other
|
|
|
|
|
|
|
|
|
|
|
Main
|
|
|
|
TNF (ligand) superfamily
|
|
|
|
|
|
|
|
|
|
|
|
|
| Other |
|
|
| By function |
|
|
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
