Interleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-30).[1] IL-27 is produced by antigen-presenting cells.[2] IL-27 plays an important function in regulating the activity of B and T lymphocytes.[3] The effects of IL-27 are eliciting by its interaction with a specific cell surface receptor complex composed of two proteins known as IL27R and gp130.[4]
References
- ^ "Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: heterogeneous expression of EBI3 subunit by tumoral cells". The American Journal of Pathology 166 (4): 1217–28. April 2005. PMID 15793300. PMC: 1602381. http://ajp.amjpathol.org/cgi/content/abstract/166/4/1217.
- ^ Lucas S, Ghilardi N, Li J, de Sauvage FJ (December 2003). "IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms". Proceedings of the National Academy of Sciences of the United States of America 100 (25): 15047–52. doi:10.1073/pnas.2536517100. PMID 14657353.
- ^ Larousserie F, Charlot P, Bardel E, Froger J, Kastelein RA, Devergne O (May 2006). "Differential effects of IL-27 on human B cell subsets". Journal of Immunology (Baltimore, Md. : 1950) 176 (10): 5890–7. PMID 16670296. http://www.jimmunol.org/cgi/content/abstract/176/10/5890.
- ^ Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA (February 2004). "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27". Journal of immunology (Baltimore, Md. : 1950) 172 (4): 2225–31. PMID 14764690. http://www.jimmunol.org/cgi/content/abstract/172/4/2225.
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