The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit[1][2] and glycoprotein 130.[3]
IL27RA essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.[4]
References
- ^ Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF (1998). "Cloning and characterization of a novel class I cytokine receptor". Biochem. Biophys. Res. Commun. 246 (1): 82–90. doi:10.1006/bbrc.1998.8576. PMID 9600072.
- ^ Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ (2000). "Development of Th1-type immune responses requires the type I cytokine receptor TCCR". Nature 407 (6806): 916–20. doi:10.1038/35038103. PMID 11057672.
- ^ Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA (February 2004). "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27". Journal of immunology (Baltimore, Md. : 1950) 172 (4): 2225–31. PMID 14764690. http://www.jimmunol.org/cgi/content/abstract/172/4/2225.
- ^ Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H (May 2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. 170 (10): 4886–90. PMID 12734330. http://www.jimmunol.org/cgi/content/abstract/170/10/4886.
External links
|
Transmembrane receptors: immune receptors |
|
| Cytokine receptor |
|
|
Interleukins ( 2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27)
CSF receptors (EPO, GM-CSF, G-CSF)
GH · prolactin · Oncostatin M · Leukemia inhibitory factor
common subunits ( Common gamma chain, common beta chain, gp130)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Other
|
|
|
|
| Other endogenous |
|
|
| Exogenous |
|
|
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
