|
Interleukin 32
|
|
| Identifiers | |
| Symbol | IL32 |
| Alt. Symbols | , NK4, TAIF, TAIFb, TAIFd |
| Entrez | 9235 |
| HUGO | 16830 |
| OMIM | 606001 |
| RefSeq | NM_004221 |
| UniProt | P24001 |
| Other data | |
| Locus | Chr. 16 p13.3 |
Interleukin 32 (IL-32) is a cytokine that can induce cells of the immune system (such as monocytes and macrophages) to secrete tumor necrosis factor-alpha (TNF-α) in addition to chemokines such as IL-8 and MIP-2/CXCL2.[1]
IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton. [2]
References
- ^ Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA. Interleukin-32: a cytokine and inducer of TNFalpha, Immunity, 2005, Volume 22, Issue 1, pages 131-42.
- ^ Mabilleau G and Sabokbar A. Interleukin-32 promotes osteoclast differentiation but not osteoclast activation, PLoS ONE, 2009, Volume 4, Issue 1, pages e4173.
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
This immunology article is a stub. You can help Wikipedia by expanding it. |
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
