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Interleukin 4 receptor
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| PDB rendering based on 1iar. | ||||||||||||||
| Available structures: 1iar | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbols | IL4R; CD124; IL4RA | |||||||||||||
| External IDs | OMIM: 147781 MGI: 105367 HomoloGene: 7784 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3566 | 16190 | ||||||||||||
| Ensembl | ENSG00000077238 | ENSMUSG00000030748 | ||||||||||||
| Uniprot | P24394 | Q3U905 | ||||||||||||
| Refseq | NM_000418 (mRNA) NP_000409 (protein) |
NM_001008700 (mRNA) NP_001008700 (protein) |
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| Location | Chr 16: 27.26 - 27.28 Mb | Chr 7: 125.36 - 125.37 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.[1]
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See also
Interactions
Interleukin-4 receptor has been shown to interact with SHC1.[2][3]
References
- ^ "Entrez Gene: IL4R interleukin 4 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3566.
- ^ Ikizawa, K; Yanagihara Y (Feb. 2000). "Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line". Biochem. Biophys. Res. Commun. (UNITED STATES) 268 (1): 54-9. doi:. ISSN 0006-291X. PMID 10652211.
- ^ Kashiwada, M; Giallourakis C C, Pan P Y, Rothman P B (Dec. 2001). "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation". J. Immunol. (United States) 167 (11): 6382-7. ISSN 0022-1767. PMID 11714803.
Further reading
- Nelms K, Keegan AD, Zamorano J, et al. (1999). "The IL-4 receptor: signaling mechanisms and biologic functions.". Annu. Rev. Immunol. 17: 701–38. doi:. PMID 10358772.
- Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT.". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. doi:. PMID 10856136.
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External links
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