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Interleukin-6 receptor

 
Wikipedia: Interleukin-6 receptor
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Interleukin 6 receptor
PBB Protein IL6R image.jpg
PDB rendering based on 1n26.
Available structures
1n26, 1p9m, 2arw
Identifiers
Symbols IL6R; CD126; IL-6R-1; IL-6R-alpha; IL6RA; MGC104991
External IDs OMIM: 147880 MGI: 105304 HomoloGene: 474
RNA expression pattern
PBB GE IL6R 205945 at tn.png
PBB GE IL6R 217489 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3570 16194
Ensembl ENSG00000160712 ENSMUSG00000027947
UniProt P08887 Q3URV7
RefSeq NM_000565 (mRNA) NM_010559 (mRNA)
NP_000556 (protein) NP_034689 (protein)
Location Chr 1:
152.64 - 152.71 Mb		 Chr 3:
89.96 - 90 Mb
PubMed search [1] [2]

Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.

Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

In melanocytic cells IL6R gene expression may be regulated by MITF[1].

Contents

Structure

The IL6 receptor is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2] IL6R subunit also shared by many other cytokines.

Interactions

Interleukin-6 receptor has been shown to interact with Interleukin 6[3] [4] [5] and Ciliary neurotrophic factor.[4][6]

See also

References

  1. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  2. ^ "Entrez Gene: IL6R interleukin 6 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3570. 
  3. ^ Schwantner, Andreas; Dingley Andrew J, Ozbek Suat, Rose-John Stefan, Grötzinger Joachim (Jan. 2004). "Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy". J. Biol. Chem. (United States) 279 (1): 571-6. doi:10.1074/jbc.M311019200. ISSN 0021-9258. PMID 14557255. 
  4. ^ a b Schuster, Björn; Kovaleva Marina, Sun Yi, Regenhard Petra, Matthews Vance, Grötzinger Joachim, Rose-John Stefan, Kallen Karl-Josef (Mar. 2003). "Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF". J. Biol. Chem. (United States) 278 (11): 9528-35. ISSN 0021-9258. PMID 12643274. 
  5. ^ Taga, T; Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T (Aug. 1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130". Cell (UNITED STATES) 58 (3): 573-81. ISSN 0092-8674. PMID 2788034. 
  6. ^ Schooltink, H; Stoyan T, Roeb E, Heinrich P C, Rose-John S (Dec. 1992). "Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes". FEBS Lett. (NETHERLANDS) 314 (3): 280-4. ISSN 0014-5793. PMID 1281789. 

Further reading

  • Krause E, Wegenka U, Möller C, et al. (1992). "Gene expression of the high molecular weight proteinase inhibitor alpha 2-macroglobulin.". Biol. Chem. Hoppe-Seyler 373 (7): 509–15. PMID 1381187. 
  • Schooltink H, Stoyan T, Roeb E, et al. (1993). "Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes.". FEBS Lett. 314 (3): 280–4. doi:10.1016/0014-5793(92)81489-9. PMID 1281789. 
  • Schooltink H, Stoyan T, Lenz D, et al. (1991). "Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells.". Biochem. J. 277 ( Pt 3): 659–64. PMID 1872801. 
  • Szpirer J, Szpirer C, Rivière M, et al. (1991). "The Interleukin-6-dependent DNA-binding protein gene (transcription factor 5: TCF5) maps to human chromosome 20 and rat chromosome 3, the IL6 receptor locus (IL6R) to human chromosome 1 and rat chromosome 2, and the rat IL6 gene to rat chromosome 4.". Genomics 10 (3): 539–46. doi:10.1016/0888-7543(91)90433-F. PMID 1889804. 
  • Sugita T, Totsuka T, Saito M, et al. (1990). "Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis.". J. Exp. Med. 171 (6): 2001–9. doi:10.1084/jem.171.6.2001. PMID 2112585. 
  • Snyers L, De Wit L, Content J (1990). "Glucocorticoid up-regulation of high-affinity interleukin 6 receptors on human epithelial cells.". Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2838–42. doi:10.1073/pnas.87.7.2838. PMID 2157217. 
  • Hibi M, Murakami M, Saito M, et al. (1991). "Molecular cloning and expression of an IL-6 signal transducer, gp130.". Cell 63 (6): 1149–57. doi:10.1016/0092-8674(90)90411-7. PMID 2261637. 
  • Novick D, Engelmann H, Wallach D, Rubinstein M (1989). "Soluble cytokine receptors are present in normal human urine.". J. Exp. Med. 170 (4): 1409–14. doi:10.1084/jem.170.4.1409. PMID 2529343. 
  • Taga T, Hibi M, Hirata Y, et al. (1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130.". Cell 58 (3): 573–81. doi:10.1016/0092-8674(89)90438-8. PMID 2788034. 
  • Yamasaki K, Taga T, Hirata Y, et al. (1988). "Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.". Science 241 (4867): 825–8. doi:10.1126/science.3136546. PMID 3136546. 
  • Horiuchi S, Koyanagi Y, Zhou Y, et al. (1994). "Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism.". Eur. J. Immunol. 24 (8): 1945–8. doi:10.1002/eji.1830240837. PMID 8056053. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Tamura T, Udagawa N, Takahashi N, et al. (1994). "Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.". Proc. Natl. Acad. Sci. U.S.A. 90 (24): 11924–8. doi:10.1073/pnas.90.24.11924. PMID 8265649. 
  • Kluck PM, Wiegant J, Jansen RP, et al. (1993). "The human interleukin-6 receptor alpha chain gene is localized on chromosome 1 band q21.". Hum. Genet. 90 (5): 542–4. doi:10.1007/BF00217455. PMID 8428753. 
  • Chirmule N, Kalyanaraman VS, Lederman S, et al. (1993). "HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6.". J. Immunol. 150 (6): 2478–86. PMID 8450224. 
  • Yawata H, Yasukawa K, Natsuka S, et al. (1993). "Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.". EMBO J. 12 (4): 1705–12. PMID 8467812. 
  • Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets.". J. Biol. Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Matsuzaki K, Katayama K, Takahashi Y, et al. (1999). "Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene.". Endocrinology 140 (2): 925–32. doi:10.1210/en.140.2.925. PMID 9927325. 

External links

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) · CD2 · CD3 (γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 (a) · CD9 · CD10 · CD11 (a, b, c) · CD13 · CD14 · CD15 · CD16 (A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 (A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 (a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 (a, b, c, d, e, f) · CD50
51-100
CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 (E, L, P) · CD63 · CD64 (A, B, C) · CD66 (a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 (a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 (a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD97 · CD98 · CD99 · CD100
101-150
CD101 · CD102 · CD103 · CD104 · CD105 · CD106 · CD107 (a, b) · CD108 · CD109 · CD110 · CD111 · CD112 · CD113 · CD114 · CD115 · CD116 · CD117 · CD118 · CD119 · CD120 (a, b) · CD121 (a, b) · CD122 · CD123 · CD124 · CD125 · CD126 · CD127 · CD129 · CD130 · CD131 · CD132 · CD133 · CD134 · CD135 · CD136 · CD137 · CD138 · CD140b · CD141 · CD142 · CD143 · CD144 · CD146 · CD147 · CD148 · CD150
151-200
CD151 · CD152 · CD153 · CD154 · CD155 · CD156 (a, b, c) · CD157 · CD158 (a, d, e, i, k) · CD159 (a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 (a, b) · CD168 · CD169 · CD170 · CD171 · CD172 (a, b, g) · CD174 · CD177 · CD178 · CD179 (a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200
201-250
CD201 · CD202b · CD204 · CD205 · CD206 · CD207 · CD208 · CD209 · CDw210 (a, b) · CD212 · CD213a (1, 2) · CD217 · CD218 (a, b) · CD220 · CD221 · CD222 · CD223 · CD224 · CD225 · CD226 · CD227 · CD228 · CD229 · CD230 · CD233 · CD234 · CD235 (a, b) · CD236 · CD238 · CD239 · CD240CE · CD241 · CD243 · CD244 · CD246 · CD247- CD248 · CD249
251-300
CD252 · CD253 · CD254 · CD256 · CD257 · CD258 · CD261 · CD262 · CD264 · CD265 · CD266 · CD267 · CD268 · CD269 · CD271 · CD272 · CD273 · CD274 · CD275 · CD276 · CD278 · CD279 · CD280 · CD281 · CD282 · CD283 · CD284 · CD286 · CD288 · CD289 · CD290 · CD292 · CDw293 · CD294 · CD295 · CD297 · CD298 · CD299
301-350
CD300A · CD301 · CD302 · CD303 · CD304 · CD305 · CD306 · CD307 · CD309 · CD312 · CD314 · CD315 · CD316 · CD317 · CD318 · CD320 · CD321 · CD322 · CD324 · CD325 · CD326 · CD328 · CD329 · CD331 · CD332 · CD333 · CD334 · CD335 · CD336 · CD337 · CD338 · CD339 · CD340 · CD344 · CD349 · CD350
v • d • e
Transmembrane receptors: immune receptors
Cytokine receptor
CSF1 · C-kit · IL-1 · IL-18
Other
Other endogenous
Other
Exogenous
TLR 1 · TLR 2 · TLR 3 · TLR 4 · TLR 5 · TLR 6 · TLR 7 · TLR 8 · TLR 9 · TLR 10
Antigen receptor
Other

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