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Interleukin 7

 
Sci-Tech Dictionary: interleukin-7
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(′in·tər¦lük·ən ′sev·ən)

(immunology) A cytokine that acts as a growth factor for precursors of B cells and T cells and also enhances the generation of interleukin-2-activated nonspecific killer cells and interleukin-2-activated antigen-specific cytotoxic T lymphocytes. Abbreviated IL-7.

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Wikipedia: Interleukin 7
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Interleukin 7
Identifiers
Symbols IL7; IL-7
External IDs OMIM: 146660 MGI: 96561 HomoloGene: 680
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3574 16196
Ensembl ENSG00000104432 ENSMUSG00000040329
Uniprot P13232 Q3UT18
Refseq NM_000880 (mRNA)
NP_000871 (protein)		 NM_008371 (mRNA)
NP_032397 (protein)
Location Chr 8: 79.81 - 79.88 Mb Chr 3: 7.56 - 7.59 Mb
Pubmed search [1] [2]

Interleukin 7 (IL7) is a hematopoietic growth factor secreted by the stromal cells of the red marrow and thymus. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells (as opposed to myeloid progenitor cells where differentiation is stimulated by IL-3) and stimulates proliferation of all cells in the lymphoid lineage (B and T lymphocytes and NK cells). It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis (From UniProt IL7_HUMAN).

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.[1]

References

  1. ^ "Entrez Gene: IL7 interleukin 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3574. 

Further reading

  • Möller P, Böhm M, Czarnetszki BM, Schadendorf D (1997). "Interleukin-7. Biology and implications for dermatology". Exp. Dermatol. 5 (3): 129–37. doi:10.1111/j.1600-0625.1996.tb00107.x. PMID 8840152. 
  • Appasamy PM (1999). "Biological and clinical implications of interleukin-7 and lymphopoiesis". Cytokines Cell. Mol. Ther. 5 (1): 25–39. PMID 10390077. 
  • Fry TJ, Mackall CL (2002). "Interleukin-7: from bench to clinic". Blood 99 (11): 3892–904. doi:10.1182/blood.V99.11.3892. PMID 12010786. 
  • Fry TJ, Mackall CL (2003). "Interleukin-7 and immunorestoration in HIV: beyond the thymus". J. Hematother. Stem Cell Res. 11 (5): 803–7. doi:10.1089/152581602760404603. PMID 12427286. 
  • Al-Rawi MA, Mansel RE, Jiang WG (2004). "Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours". Histol. Histopathol. 18 (3): 911–23. PMID 12792903. 
  • Aspinall R, Henson S, Pido-Lopez J, Ngom PT (2004). "Interleukin-7: an interleukin for rejuvenating the immune system". Ann. N. Y. Acad. Sci. 1019: 116–22. doi:10.1196/annals.1297.021. PMID 15247003. 
  • Snyder KM, Mackall CL, Fry TJ (2007). "IL-7 in allogeneic transplant: clinical promise and potential pitfalls". Leuk. Lymphoma 47 (7): 1222–8. doi:10.1080/10428190600555876. PMID 16923550. 
  • Brunton LL, Lupton SD (1990). "An STS in the human IL7 gene located at 8q12-13". Nucleic Acids Res. 18 (5): 1315. doi:10.1093/nar/18.5.1315. PMID 2320434. 
  • Lupton SD, Gimpel S, Jerzy R, et al. (1990). "Characterization of the human and murine IL-7 genes". J. Immunol. 144 (9): 3592–601. PMID 2329282. 
  • Goodwin RG, Lupton S, Schmierer A, et al. (1989). "Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 302–6. doi:10.1073/pnas.86.1.302. PMID 2643102. 
  • Sutherland GR, Baker E, Fernandez KE, et al. (1989). "The gene for human interleukin 7 (IL7) is at 8q12-13". Hum. Genet. 82 (4): 371–2. doi:10.1007/BF00274000. PMID 2786840. 
  • Muegge K, Vila MP, Durum SK (1993). "Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene". Science 261 (5117): 93–5. doi:10.1126/science.7686307. PMID 7686307. 
  • Watanabe M, Ueno Y, Yajima T, et al. (1995). "Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes". J. Clin. Invest. 95 (6): 2945–53. doi:10.1172/JCI118002. PMID 7769137. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Noguchi M, Nakamura Y, Russell SM, et al. (1994). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor". Science 262 (5141): 1877–80. doi:10.1126/science.8266077. PMID 8266077. 
  • Sica D, Rayman P, Stanley J, et al. (1993). "Interleukin 7 enhances the proliferation and effector function of tumor-infiltrating lymphocytes from renal-cell carcinoma". Int. J. Cancer 53 (6): 941–7. PMID 8473051. 
  • Kroemer RT, Doughty SW, Robinson AJ, Richards WG (1996). "Prediction of the three-dimensional structure of human interleukin-7 by homology modeling". Protein Eng. 9 (6): 493–8. doi:10.1093/protein/9.6.493. PMID 8862549. 
  • Kroemer RT, Richards WG (1997). "Homology modeling study of the human interleukin-7 receptor complex". Protein Eng. 9 (12): 1135–42. doi:10.1093/protein/9.12.1135. PMID 9010926. 
  • Kim JH, Loveland JE, Sitz KV, et al. (1997). "Expansion of restricted cellular immune responses to HIV-1 envelope by vaccination: IL-7 and IL-12 differentially augment cellular proliferative responses to HIV-1". Clin. Exp. Immunol. 108 (2): 243–50. doi:10.1046/j.1365-2249.1997.d01-1006.x. PMID 9158092. 
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