Standardized preparations of biologically active substances are held as samples of archive in Copenhagen (immunologicals) and London (pharmacologicals),
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[Burn J. H., Finney D. J., Goodwin L. C. Biological Standardization,
| diphtheria antitoxin | 1922 | 62.8 | μg |
| arsphenamine | 1925 | 1. | mg |
| neoarsphenamine | 1925 | 1. | mg |
| sulpharsphenamine | 1925 | 1. | mg |
| insulin (crude dry insulin hydrochloride) | 1925 | 125. | μg |
| pituitary (posterior lobe) powder | 1925 | 500. | μg |
| digitalis | 1925 | 80. | mg |
| ouabain | 1925 | 80. | mg |
| tetanus antitoxin | 1928 | 154.7 | μg |
| anti-dysentery serum (Shiga) | 1928 | 500. | μg |
| vitamin A* (mixed carotenes) | 1931 | 1. | μg |
| vitamin B1 (adsorption product of) | 1931 | 10. | mg |
| vitamin D (irradiated ergosterol solution) | 1931 | 100. | μg |
Since those years some have been redefined, while very many others have been established. Current definitions, using hash marks appended to indicate redefinitions (with one mark for a first redifinition, two marks for a second, etc.), include those set out in Table 28.
| Antigens | |||
| diphtheria toxoid (plain, alcohol purified) | 1951 | 500. | μg |
| diphtheria toxoid (adsorbed to Al(OH)2, dried) | 1955 | 750. | μg |
| diphtheria - Shick test toxin (purified) | 1954 | 4.2 | μg |
| old tuberculin | 1935″ | 10. | μg |
| pertussis vaccine (dried) | 1957 | 1 500. | μg |
| swine erysipelas vaccine (adsorbed to Al(OH)2, dried) | 1959 | 750. | μg |
| tetanus toxoid (alcohol purified) | 1951 | 30. | μg |
| Antibodies (hyperimmune horse serum except as | |||
| shown) | |||
| gas-gangrene serum (dried) | |||
| perfingens Chlostridium welchii Type A | 1953″″ | 113.2 | μg |
| perfingens Chlostridium welchii Type B | 1954 | 13.7 | μg |
| perfingens Chlostridium welchii Type D | 1954 | 65.7 | μg |
| vibrion septique | 1954″′ | 11.8 | μg |
| * but see RE. | |||
| oedematiens | 1952″ | 113.5 | μg |
| hystoliyticus | 1951″ | 200. | μg |
| Sordelli | 1938 | 133.4 | μg |
| staphylococcus α antitoxin (dried) | 1938″ | 237.6 | μg |
| scarlet fever staphylococcus antitoxin (dried) | 1952 | 49. | μg |
| swine erysipelas serum (anti-N) | 1954 | 140. | μg |
| antistreptolysinanO (human, dried) | 1959 | 21.3 | μg |
| antipneumococcus serum type 1 (dried) | 1934 | 88.6 | μg |
| antipneumococcus serum type 2 (dried) | 1934 | 89.4 | μg |
| anti-Brucella abortus serum (bovine, dried) | 1952 | 91. | μg |
| anti-Q-fever serum (bovine, dried) | 1953 | 101.7 | μg |
| anti-rabies serum (dried) | 1955 | 1 000. | μg |
| anti-A blood-typing serum (human, dried) | 1950 | 346.5 | μg |
| anti-B blood-typing serum (human, dried) | 1950 | 352. | μg |
| syphilitic human serum (dried) | 1958 | 3 617. | μg |
| Antibiotics | |||
| penicillin (sodium benzyl…) | 1944 | 0.6 | μg |
| 1952″ | 0.5988 | μg | |
| phenoxymethylpenicillin (sodium benzyl…) | 1957 | 0.59 | μg |
| streptomycin (…sulphate) | 1958 | 1.282 | μg |
| dihydrotreptomycin (…sulphate) | 1953 | 1.316 | μg |
| bacitracin | 1953 | 18.2 | μg |
| tetracycline (…hydrochloride) | 1957 | 1.01 | μg |
| chlortetracycline (…hydrochloride) | 1953 | 1. | μg |
| oxytetracycline (…dihydrate) | 1955 | 1.11 | μg |
| oeryhromycin (…dihydrate) | 1957 | 1.053 | μg |
| polymyxin B (…sulphate, purified) | 1955 | 0.127 | μg |
| Hormones | |||
| insulin (pure crystalline insulin) | 1935 | 45.5 | μg |
| poxytoxic, vasosuppressor and anti-diuretic substances | |||
| (posterior ox pituitary, acetone-dried, powdered) | 1957″′ | 500. | μg |
| prolactin (active principle anterior ox pituitary, dried) | 1939 | 100. | μg |
| corticotropin ACTH (pig pituitary, crude) | 1955″ | 880. | μg |
| thyrotropin (anterior ox pituitary, crude) | 1954 | 13 500. | μg |
| Vitamins and Miscellaneous | |||
| digitalis (dry powdered leaf of D purpurea) | 1949″ | 76.0 | μg |
| hyaluronidase (bovine testes, dried) | 1955 | 100. | ng |
| vitamin D3 | 1949″ | 0.025 | μg |
| vitamin B1 (pure synthetic form) | 1938 | 3.0 | μg |
| vitamin C (t-ascorbic acid) | 1934 | 50.0 | μg |
| vitamin E (α-tocopheryl acetate) | 1941 | 1.0 | mg |
| heparin | 1942 | 7.7 | μg |
| The ′marks indicate successor versions. |
