Interstate 680 is the designation for several Interstate Highways in the United States, all of which are related to Interstate 80:
- Interstate 680 (California), a connection to I-280 in San Jose, California
- Interstate 680 (Iowa-Nebraska), a bypass of Omaha, Nebraska
- Interstate 680 (Ohio), a loop through Youngstown, Ohio
The following roads used to be numbered I-680:
- Interstate 676, back when I-76 was I-80S.
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