|
Transcription factors and intracellular receptors |
|
|
(1) Basic domains |
|
|
|
Activating transcription factor ( AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 ( c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) · BACH ( 1, 2) · BATF · BLZF1 · C/EBP ( α, β, γ, δ, ε, ζ) · CREB ( 1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF ( B, F, G, K) · NFE ( 2, L1, L2) · NFIL3 · NRL · NRF1 · XBP1
|
|
(1.2) Basic helix-loop-helix ( bHLH)
|
ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLHB2 · BMAL ( ARNTL, ARNTL2) · CLOCK · EPAS1 · HAND ( 1, 2) · HES ( 5, 6) · HEY ( 1, 2, L) · HES1 · HIF ( 1A, 3A) · ID ( 1, 2, 3, 4) · LYL1 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors ( MyoD, Myogenin, MYF5, MYF6) · Neurogenins · NeuroD ( 1, 2) · NPAS ( 1, 2, 3) · OLIG ( 1, 2) · Pho4 · Scleraxis · TAL ( 1, 2) · Twist · USF1
|
|
|
|
|
|
|
(1.4) NF-1
|
|
|
|
(1.5) RF-X
|
|
|
|
(1.6) Basic helix-span-helix (bHSH)
|
|
|
|
|
|
(2) Zinc finger DNA-binding domains |
|
|
|
subfamily 1 ( Thyroid hormone ( α, β), CAR, FXR, LXR ( α, β), PPAR ( α, β/δ, γ), PXR, RAR ( α, β, γ), ROR ( α, β, γ), Rev-ErbA ( α, β), VDR)
subfamily 2 ( COUP-TF ( I, II), Ear-2, HNF4 ( α, γ), PNR, RXR ( α, β, γ), Testicular receptor ( 2, 4), TLX)
subfamily 3 ( Steroid hormone ( Androgen, Estrogen ( α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related ( α, β, γ))
subfamily 4 NUR ( NGFIB, NOR1, NURR1) · subfamily 5 ( LRH-1, SF1) · subfamily 6 ( GCNF) · subfamily 0 ( DAX1, SHP)
|
|
|
(2.2) Other Cys4
|
|
|
|
(2.3) Cys2His2
|
General transcription factors ( TFIIA, TFIIB, TFIID, TFIIE, TFIIF ( 1, 2), TFIIH ( 1, 2, 4, 2I, 3A, 3C1, 3C2))
ATBF1 · BCL ( 6, 11A, 11B) · CTCF · E4F1 · EGR ( 2, 3) · ERV3 · GFI1 · GLI-Krüppel family ( 1, 2, 3, REST, S2, YY1) · HIC ( 1, 2) · HIVEP ( 1, 2, 3) · IKZF ( 1, 2, 3) · ILF ( 2, 3) · KLF ( 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17) · MTF1 · MYT1 · OSR1 · SP ( 1, 2, 4, 7) · Zbtb7 ( 7A, 7B) · ZBTB ( 16, 17, 20, 32, 33, 40) · zinc finger ( 3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 649, 655)
|
|
|
(2.4) Cys6
|
|
|
|
(2.5) Alternating composition
|
|
|
|
|
|
(3) Helix-turn-helix domains |
|
|
|
ARX · CDX ( 1, 2) · CRX · CUTL1 · DLX ( 3, 4, 5) · EMX2 · EN ( 1, 2) · FHL ( 1, 2, 3) · HESX1 · HHEX · HLX · Homeobox ( A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · LMX ( 1A, 1B) · MEIS ( 1, 2) · MEOX2 · MNX1 · MSX ( 1, 2) · NANOG · NKX ( 2-1, 2-2, 2-3, 2-5, 3-1, 3-2) · PBX ( 1, 2, 3) · PHF ( 1, 3, 6, 8, 10, 16, 17, 20, 21A) · PITX ( 1, 2, 3) · POU domain ( PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX ( 1, 2) · PDX1 · ZEB ( 1, 2)
|
|
|
(3.2) Paired box
|
|
|
|
|
E2F ( 1, 2, 3, 4, 5) · FOX proteins ( C1, C2, D3, E1, G1, H1, K2, L2, M1, N3, O1, O3, O4, P1, P2, P3)
|
|
|
|
|
|
|
(3.5) Tryptophan clusters
|
ELF ( 2, 4, 5) · EGF · ELK ( 1, 3, 4) · ERF · ERG · ETS ( 1, 2, SPIB) · ETV ( 1, 4, 5, 6) · FLI1 · Interferon regulatory factors ( 1, 2, 3, 4, 5, 6, 7, 8) · MYB · MYBL2
|
|
|
(3.6) TEA domain
|
transcriptional enhancer factor ( 1, 2, 3, 4)
|
|
|
|
|
(4) β-Scaffold factors with minor groove contacts |
|
|
|
|
|
|
|
|
|
|
(4.3) p53
|
|
|
|
|
|
|
|
|
|
|
|
|
HMGB ( 1, 2, 3) · HNF ( 1A, 1B) · LEF1 · SOX ( 1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY · SSRP1 · TCF ( 3, 4) · TOX ( 1, 2, 3, 4)
|
|
|
(4.10) Cold-shock domain
|
|
|
|
(4.11) Runt
|
|
|
|
|
|
(0) Other transcription factors |
|
|
(0.2) HMGI(Y)
|
|
|
|
|
|
|
|
|
|
|
|
(0.6) Miscellaneous
|
ARID ( 1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI ( 16, 35) · MLL ( 2, 3, T1) · MNDA · NFY ( A, B, C) · Rho/ Sigma
|
|
|
|
