IRS

IRS commonly may mean:

Medicine

• Indoor residual spraying, the spraying of insecticide to kill the mosquitoes that spread malaria
• Insulin receptor substrate, a protein family involved in the insulin signaling pathway (insulin response)
• Intergroup Rhabdomyosarcoma Study Group, about the cancer, rhabdomyosarcoma

Economics

• The United States Internal Revenue Service
• Indian Revenue Service (IRS)
• Interest rate swap
• International Retail Service, a service provided by the London Stock Exchange

Music

• I.R.S. Records
• IRS (Guns N' Roses Song), a song by Guns N' Roses featured on their album, Chinese Democracy

Space

• Indian Remote Sensing satellite

Transportation

• Independent rear suspension, a form of Independent suspension, used in automobiles
• Industrial Railway Society, a UK railway society
• inertial reference system, more commonly known as an inertial navigation system.

Other

• Information Retrieval System in Computer Science
• Institute of Regional Studies
• Integrated reception system for TV and radio signals
• Irwin R. Schyster, often abbreviated I.R.S., a ring name of professional wrestler Mike Rotunda

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