isomerase

In biochemistry, an isomerase is an enzyme that catalyzes the structural rearrangement of isomers. Isomerases thus catalyze reactions of the form

A → B

where B is an isomer of A.

Nomenclature

The names of isomerases are formed as "substrate isomerase" (for example, enoyl CoA isomerase), or as "substrate type of isomerase" (for example, phosphoglucomutase).

Classification

Isomerases have their own EC classification of enzymes: EC 5. Isomerases can be further classified into six subclasses:

• EC 5.1 includes enzymes that catalyze racemization (racemases) and epimerization (epimerases)
• EC 5.2 includes enzymes that catalyze the isomerization of geometric isomers (cis-trans isomerases)
• EC 5.3 includes intramolecular oxidoreductases
• EC 5.4 includes intramolecular transferases (mutases)
• EC 5.5 includes intramolecular lyases
• EC 5.99 includes other isomerases (including topoisomerases)

References

• EC 5 Introduction from the Department of Chemistry at Queen Mary, University of London
• isomerase." Dorland's Medical Dictionary for Health Consumers. 2007. Saunders, an imprint of Elsevier, Inc 6 Nov. 2009 http://medical-dictionary.thefreedictionary.com/isomerase
• [[isomerase." Webster's New World College Dictionary. LoveToKnow, n.d. Web. 6 November 2009. <http://www.yourdictionary.com/isomerase]]

External links

• GoPubMed: Top authors, journals, places publishing on Isomerases

Enzyme catalysis - Enzyme inhibitor - Enzyme kinetics - Lineweaver–Burk plot - Michaelis–Menten kinetics - List of enzymes