| Dental Dictionary: isosorbide dinitrate |
trade names: Iso-Bid, Isotrate, Dilatrate-SR, Isordil; drug class: nitrate antianginal; action: decreases preload/afterload, which is responsible for decreasing left ventricular end-diastolic pressure, systemic vascular resistance; uses: chronic stable angina pectoris, prophylaxis of angina pain.
| 5min Related Video: Isosorbide dinitrate |
| Drug Info: Isosorbide Dinitrate, ISDN |
Brand names: Dilatrate®-SRIsochron™Isordil® Titradose®Sorbitrate®Sorbitrate® ChewableWesorbide™
Chemical formula:
Isosorbide Dinitrate Oral tablet
What is this medicine?
ISOSORBIDE DINITRATE is a type of vasodilator. It relaxes blood vessels, increasing the blood and oxygen supply to your heart. This medicine is used to prevent chest pain caused by angina. It will not help to stop an episode of chest pain.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
•previous heart attack or heart failure
•an unusual or allergic reaction to isosorbide dinitrate, nitrates, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, at least 30 minutes before or 2 hours after food. Do not take with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly or your symptoms may get worse. Ask your doctor or health care professional how to gradually reduce the dose.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you have been instructed to use ardeparin on a regular schedule, use missed doses as soon as you remember, unless it is almost time for the next dose. Do not use double doses.What may interact with this medicine?
Do not take this medicine with any of the following medications:
•medicines used to treat erectile dysfunction (ED) like sildenafil, tadalafil, and vardenafil
This medicine may also interact with the following medications:
•medicines for high blood pressure
•other medicines for angina or heart failure
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Check your heart rate and blood pressure regularly while you are taking this medicine. Ask your doctor or health care professional what your heart rate and blood pressure should be and when you should contact him or her. Tell your doctor or health care professional if you feel your medicine is no longer working.
You may get dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can make you more dizzy, and increase flushing and rapid heartbeats. Avoid alcoholic drinks.
Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
•bluish discoloration of lips, fingernails, or palms of hands
•irregular heartbeat, palpitations
•low blood pressure
•nausea, vomiting
•persistent headache
•unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•flushing of the face or neck
•rash
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature, approximately 25 degrees C (77 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
| Wikipedia: Isosorbide dinitrate |
 |
|
| Systematic (IUPAC) name | |
|---|---|
| 1,4:3,6-dianhydro-2,5-di-O-nitro-D-glucitol | |
| Identifiers | |
| CAS number | 87-33-2 |
| ATC code | C01DA08 D03AX08 |
| PubChem | 3780 |
| DrugBank | APRD00455 |
| Chemical data | |
| Formula | C6H8N2O8 |
| Mol. mass | 236.136 g/mol |
| SMILES | eMolecules & PubChem |
| Synonyms | (3R,3aS,6S,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl dinitrate |
| Pharmacokinetic data | |
| Bioavailability | 10–90%, average 25% |
| Metabolism | Hepatic |
| Half life | 1 hour |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status |
℞ Prescription only |
| Routes | Oral |
 (what is this?) (verify) |
|
Isosorbide dinitrate (ISDN) (also known as Dilatrate) is a nitrate used pharmacologically as a vasodilator, e.g. in angina pectoris but also for anal fissure, a condition which is known to involve decreased blood supply leading to poor healing. It is also used as a direct vasodilator to treat congestive heart failure.
Isosorbide dinitrate is sold under the brand names Isordil[1] by Biovail, Cedocard and Sorbitrate. In UK and Hong Kong, a trade name of it is Isoket. It is also a component of BiDil.
Contents |
It is more useful in preventing angina attacks than reversing them once they have commenced. It may be given as a tablet for the treatment of an angina attack.
Long acting nitrates can be more useful as they are generally more effective and stable in the short term. it is more effective with African Americans.
After long term use for treating chronic conditions, tolerance may develop in a patient reducing its effectiveness. The mechanisms of nitrate tolerance have been thoroughly investigated in the last 30 years and several hypotheses have been proposed. these include:
Recent evidence suggests that the latter hypothesis might represent a unifying hypothesis, and an ISDN-induced inappropriate production of oxygen free radicals might induce a number of abnormalities which include the ones described above. Furthermore, studies have shown that nitrate tolerance is associated with vascular abnormalities which have the potential to worsen patients prognosis (Nakamura et al.): these include endothelial and autonomic dysfunction (Gori et al.). In the short run, ISDN can cause severe headaches, necessitating analgesic (very rarely up to morphine) administration for relief of pain as well as severe hypotension, and, in certain cases, bradycardia. This makes some physicians nervous and should prompt caution when starting nitrate administration.
|
||||||||||||||
|
||||||||
i luv u
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
 | Hydralazine; Isosorbide Dinitrate, ISDN |
| isosorbide |
| Hydralazine; Isosorbide Dinitrate, ISDN tablet |
 | What is isosorbide monohydrate? Read answer... |
| What is isosorbide mononitrate? Read answer... |
 | Why does the amount of the dinitration increase at high temperatures? |
| What is the reaction of sodium dinitrate and hydrochloric acid? |
| What would cause extreme itching from Isosorbide? |
Copyrights:
 |
 | Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved. Read more |
 |
| Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved. Read more |
 |
| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Isosorbide dinitrate". Read more |
Mentioned in
