Jane Gray Muskie (February 12, 1927 – December 25, 2004) was the wife of U.S. senator and 1968 vice presidential candidate Edmund Muskie. Edmund Muskie's 1972 presidential campaign collapsed after his emotional defense of his wife, following the Canuck letter incident, which involved a scathing editorial in the conservative Manchester Union-Leader newspaper. The editorial alleged that Jane Muskie enjoyed excessive drinking and telling dirty jokes.
After Edmund Muskie died in 1996, Jane Muskie retreated to private life. She died at only 77 quietly at her home in Bethesda, Maryland, on December 25, 2004, after a bout with Alzheimer's disease.
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