Janeway lesion: Definition from Answers.com

Janeway lesions are non-tender, small erythematous or haemorrhagic macular or nodular lesions on the palms or soles only a few millimeters in diameter that are pathognomonic of infective endocarditis.^[1] Pathologically, the lesion is described to be a microabscess of the dermis with marked necrosis and inflammatory infiltrate not involving the epidermis, which is due to the deposition of circulating immune complexes in small blood vessels.^[1]

Osler's nodes and Janeway lesions are similar, but Osler's nodes present with tenderness.^[2]

Eponym

They are named after Edward G. Janeway (1841–1911), an American professor of medicine with interests in cardiology and infectious disease.^[3]

^ ^a ^b Farrior, J.B.; Silverman M.E. (1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest. 70 (2): 239–43. doi:10.1378/chest.70.2.239. PMID 947688.
^ Farrior JB, Silverman ME (August 1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest 70 (2): 239–43. PMID 947688. http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=947688.
^ Janeway C. (1998). "Presidential Address to The American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response". J. Immunol. 161 (2): 539–44. PMID 9670925.

Blood flow

Heart

Obstructive lung disease	COPD (Hoover's sign) · asthma (Curschmann's spirals, Charcot-Leyden crystals) · chronic bronchitis (Reid index)

Restrictive lung disease	sarcoidosis (Kveim test)

Dyspnea	Biot's respiration · Cheyne-Stokes respiration · Kussmaul breathing

Other/general	clubbing (Schamroth's window test/Hippocratic fingers) pulmonary embolism (Hampton hump, Westermark sign) pulmonary edema (Kerley lines)

Chest - general

see also Circulatory and respiratory system symptoms and signs

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