John Henry may refer to:
People
- John Henry (folklore), the "steel-driving man", American folk hero
- John Henry, Margrave of Moravia (1322–1375)
- John Henry (Maryland) (1750–1798), U.S. Senator from and Governor of Maryland
- John Joseph Henry (1758–1811), American Revolutionary War soldier
- John Vernon Henry (1767–1829), American politician, New York State Comptroller
- John Henry (spy) (c. 1776–1853), British spy
- John Flournoy Henry (1793–1873), U.S. Representative from Kentucky
- John Henry (representative) (1800–1882), U.S. Representative from Illinois
- John Henry (toxicologist) (1939–2007), English toxicologist, professor at Imperial College London and a consultant to Britain's National Poisons Information Service
- John W. Henry (born 1949), American businessman, principal owner of the Boston Red Sox
- John Henry (historian), British historian of science associated with the Strong Programme
- John Henry (New Zealand Justice), New Zealand Privy Councillor and Court of Appeal Justice
- John Henry (vocalist), vocalist in the metalcore band Darkest Hour
- John Henry (catcher) (1889–1941), major league baseball catcher, 1910–1918
- John Henry (outfielder/pitcher) (1863–1939), major league baseball outfielder/pitcher, 1884–1890
- Jack Henry, American football player
- John Snowdon Henry (died 1896), British Conservative Member of Parliament (MP) for South-East Lancashire
In fiction
Other
See also
- John Henryism, a psychological term for a type of coping behaviours
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