The Keratinocyte Growth Factor (KGF), also known as FGF7, is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium.
KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b).[1] For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin.
There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.
FGF10 is also known as "Keratinocyte growth factor 2".[2]
See also
References
- ^ Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A (2008). "Silencing of keratinocyte growth factor receptor restores 5-fluorouracil and tamoxifen efficacy on responsive cancer cells". PLoS ONE 3 (6): e2528. doi:. PMID 18575591. PMC: 2424182. http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002528.
- ^ "iHOP - Information Hyperlinked over Proteins [ FGF10 ]". http://www.ihop-net.org/UniPub/iHOP/gs/88201.html.
External links
- http://www-personal.umich.edu/~lpt/fgf/1fq9_files/side.jpg
- http://www-personal.umich.edu/~lpt/fgf/1fq9.htm
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