|
kallikrein-related peptidase 9
|
|
| Identifiers | |
| Symbol | KLK9 |
| Entrez | 284366 |
| HUGO | 6370 |
| OMIM | 605504 |
| RefSeq | NM_012315 |
| UniProt | Q9UKQ9 |
| Other data | |
| Locus | Chr. 19 q13.33 |
Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene.[1]
Function
KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues.[2][3][4] KLK9 is primarily expressed in thymus, testis, spinal cord, cerebellum, trachea, mammary gland, prostate, brain, salivary gland, ovary, and skin.[1]
Clinical significance
KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stage ovarian[5] and breast cancer patients.[6]
References
- ^ a b Yousef GM, Diamandis EP (April 2000). "The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9)". Genomics 65 (2): 184–94. doi:. PMID 10783266.
- ^ "Entrez Gene: KLK9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=284366.
- ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol. Chem. 387 (6): 637–41. doi:. PMID 16800724.
- ^ "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol. Chem. 387 (6): 635–824. June 2006. doi:. PMID 16800723.
- ^ Yousef GM, Kyriakopoulou LG, Scorilas A, Fracchioli S, Ghiringhello B, Zarghooni M, Chang A, Diamandis M, Giardina G, Hartwick WJ, Richiardi G, Massobrio M, Diamandis EP, Katsaros D (November 2001). "Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker". Cancer Res. 61 (21): 7811–8. PMID 11691797. http://cancerres.aacrjournals.org/cgi/content/abstract/61/21/7811.
- ^ Yousef GM, Scorilas A, Nakamura T, Ellatif MA, Ponzone R, Biglia N, Maggiorotto F, Roagna R, Sismondi P, Diamandis EP (March 2003). "The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer". Breast Cancer Res. Treat. 78 (2): 149–58. doi:. PMID 12725415.
 |
This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it. |
|
||||||||||||||||||||
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
