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Lansoprazole

 
Dental Dictionary: lansoprazole

n

trade name: Prevacid; drug class: antisecretory, proton pump inhibitor; action: suppresses gastric secretion by inhibiting hydrogen/ potassium ATPase enzyme system in gastric parietal cell; uses: short-term treatment for healing and symptomatic relief of active duodenal ulcer and erosive esophagitis.

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WordNet: lansoprazole
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Note: click on a word meaning below to see its connections and related words.

The noun has one meaning:

Meaning #1: antacid (trade name Prevacid) that suppresses acid secretion in the stomach
  Synonym: Prevacid


Wikipedia: Lansoprazole
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Lansoprazole
Systematic (IUPAC) name
2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole
Identifiers
CAS number 103577-45-3
ATC code A02BC03
PubChem 3883
DrugBank APRD00077
ChemSpider 3746
Chemical data
Formula C16H14F3N3O2S 
Mol. mass 369.363 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 80% or more
Protein binding 97%
Metabolism Hepatic (CYP3A4- and CYP2C19-mediated)
Half life 1–1.5 hours
Excretion Renal and fecal
Therapeutic considerations
Licence data

US FDA:link

Pregnancy cat.

B3(AU) B(US)

Legal status

Rx Only (US)

Routes Oral, IV
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Lansoprazole (pronounced /lænˈsoʊprəzoʊl/, lan-SOE-pra-zole, INN) is a proton pump inhibitor which prevents the stomach from producing acid. It is manufactured by a number of companies worldwide under several brand names (some brand names include: Prevacid, Helicid, Zoton, Inhibitol). It was first approved by the FDA in 1995.[1] Prevacid patent protection expires on Nov. 10, 2009.[2]

Contents

Pharmacology

Lansoprazole is a proton pump inhibitor (PPI) in the same pharmacologic class as omeprazole. Lansoprazole has been marketed for many years and is one of several PPIs available.[3]

Lansoprazole's plasma elimination half-life is not proportional to the duration of the drug's effects (i.e. gastric acid suppression). The mean plasma elimination half-life is 1.5 hours,[4] and the effects of the drug last for over 24 hours after it has been used for 1 day or more.[citation needed]

Indications

Lansoprazole is indicated for:

Drug Interactions

Side effects

Proton pump inhibitors may be associated with a greater risk of hip fractures,[5] clostridium difficile-associated diarrhea.[6] Patients are frequently administered the drugs in intensive care as a protective measure against ulcers, but this use is also associated with a 30% increase in occurrence of pneumonia.[7]

Brand names

Prevacid 30 mg

The drug is sold under several brand names, including: [1]

  • Agopton (Germany)
  • Aprazol (Turkey)
  • Digest (Indonesia)
  • Duogast (Syria)
  • Lanpro (India)
  • Lanzol (India)
  • Lanzul (Slovenia)
  • Lansoptol (Hungary)
  • Lansox (Italy)
  • Lansoloc (South Africa)
  • Lanton (Israel)
  • Lanzor (France)
  • Laprazol (Greece)
  • Lanciprol (Greece)
  • Limpidex (Italy)
  • Monolitum (Spain)
  • Ogast and OgastORO (France)
  • Ogastro (Mexico)
  • Prevacid (U.S. and Canada) Prevacid is a product of Takeda Pharmaceuticals.
  • pro-ulco (Spain)
  • Prosogan and Prosogan FD (Indonesia)
  • Refluxon (Hungary)
  • SOLOX (New Zealand)
  • Takepron (Japan)
  • Zoton (Italy, Ireland, Australia, UK)
  • ZOMEL (Ireland)

Lansoprazole is also available as a generic drug in the UK, Canada, Belgium, France, Colombia, Italy and Mexico.

References

  1. ^ a b Mosby's Drug Consult: Lansoprazole
  2. ^ Teva to release Prevacid version when patent expires
  3. ^ http://www.patient.co.uk/showdoc/30002943/
  4. ^ a b "Prevacid Pharmacology, Pharmacokinetics, Studies, Metabolism". RxList.com. 2007. http://www.rxlist.com/cgi/generic/lansop_cp.htm. Retrieved 2007-04-14. 
  5. ^ Yang YX, Lewis JD, Epstein S, Metz DC (2006). "Long-term Proton Pump Inhibitor Therapy and Risk of Hip Fracture". JAMA 296 (24): 2947–53. doi:10.1001/jama.296.24.2947. PMID 17190895. 
  6. ^ "Proton pump inhibitors and Clostridium difficile". Bandolier. 2003. http://www.medicine.ox.ac.uk/bandolier/booth/Pharmacy/PPIcdiff.html. Retrieved 2007-07-13. 
  7. ^ Shoshana J. Herzig, MD; Michael D. Howell, MD, MPH; Long H. Ngo, PhD; Edward R. Marcantonio, MD, SM (2009). "Acid-Suppressive Medication Use and the Risk for Hospital-Acquired Pneumonia=JAMA". JAMA the Journal of the American Medical Association 301 (20): 2120–2128. doi:10.1001/jama.2009.722. PMID 19470989. http://jama.ama-assn.org/cgi/content/abstract/301/20/2120?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=shoshana+herzig&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT. 

External links


 
 

 

Copyrights:

Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved.  Read more
WordNet. WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Lansoprazole" Read more