Share on Facebook Share on Twitter Email
Answers.com

levonorgestrel

 
Dictionary: le·vo·nor·ges·trel
('və-nôr-jĕs'trəl) pronunciation
n.
The levorotatory form of norgestrel, used in oral contraceptives and in contraceptives implanted subdermally. In implant form it can prevent pregnancy for up to five years.


Search unanswered questions...
Enter a question here...
Search: All sources Community Q&A Reference topics
Drug Info: Levonorgestrel
Top

Brand names: Mirena®Norplant®Plan B®

Chemical formula:



Levonorgestrel implant capsules

What are levonorgestrel implant capsules?

LEVONORGESTREL (Norplant®) is a contraceptive (birth control) device that is surgically implanted under the skin. The device releases the hormone levonorgestrel, a progestin, in the body to prevent pregnancy for up to 5 years. Once the implant capsules are removed, fertility quickly returns to normal. Generic levonorgestrel implant capsules are not yet available. NOTE: Norplant® is discontinued in the US as of mid-2002.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• blood vessel disease, or blood clotting disorder
• breast cancer
• diabetes
• disturbed eyesight
• heart disease
• kidney disease
• liver disease
• tobacco smoker
• vaginal bleeding
• an unusual or allergic reaction to levonorgestrel, other hormones, medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Levonorgestrel implant capsules are surgically implanted under the skin by a health-care professional.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply.

What drug(s) may interact with levonorgestrel?

• aprepitant, a medicine used for chemotherapy-induced nausea and vomiting
• barbiturate medicines for inducing sleep or treating seizures (convulsions)
bosentan
carbamazepine
griseofulvin
modafinil
oxcarbazepine
phenytoin
rifabutin
rifampin
rifapentine
ritonavir
• St. John's wort
topiramate
• troglitazone or pioglitazone

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking levonorgestrel?

Visit your prescriber or health care professional for regular checks on your progress. You should have a complete check-up every 6 to 12 months.

Tobacco smoking increases the risk of getting a blood clot or having a stroke while you are using levonorgestrel, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye prescriber or health care professional.

Levonorgestrel skin implants do not protect you against HIV infection (AIDS) or other sexually transmitted diseases.

What side effects may I notice from using levonorgestrel?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• dizziness or fainting spells
• leg, arm or groin pain
• severe headache
• sudden shortness of breath
• swelling of the hands, feet or ankles, or rapid weight gain
• vision or speech problems

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• acne
• breakthrough bleeding, spotting, irregular menstrual cycle, or no menstruation
• breast discharge
• facial hair growth
• fluid retention and swelling
• loss of appetite or increase in appetite
• mood changes, anxiety, depression, frustration, anger, or emotional outbursts
• nausea, vomiting
• pain or itching at the place where the implant was inserted
• skin rash
• stomach discomfort
• vaginal yeast infection (irritation and white discharge)

Where can I keep my medicine?

This does not apply.


Last updated: 8/19/2004 10:51:00 AM

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

Wikipedia: Levonorgestrel
Top
Levonorgestrel
Systematic (IUPAC) name
13-ethyl-17-ethynyl-17-hydroxy- 1,2,6,7,8,9,10,11,12,13,14,15,16, 17- tetradecahydrocyclopenta[a] phenanthren-3-one
Identifiers
CAS number 797-63-7
ATC code G03AC03
PubChem 13109
DrugBank APRD00754
ChemSpider 12560
Chemical data
Formula C21H28O2 
Mol. mass 312.446 g/mol
Pharmacokinetic data
Bioavailability ~100%
Protein binding 55%
Metabolism Hepatic
Half life 36 ± 13 hours
Excretion Renal: 45%; Fecal:32%
Therapeutic considerations
Pregnancy cat.

X

Legal status
Routes Implant; insert (extended-release); oral
 Yes check.svgY(what is this?)  (verify)

Levonorgestrel (or l-norgestrel or D-norgestrel) is a synthetic progestogen used as an active ingredient in some hormonal contraceptives.

Contents

Chemistry

Chemically, it is a hormonally active levorotatory enantiomer of the racemic mixture norgestrel. It is a gonane progestin derived from 19-nortestosterone.[1]

Its in vitro relative binding affinities at human steroid hormone receptors are: 323% that of progesterone at the progesterone receptor, 58% that of testosterone at the androgen receptor, 17% that of aldosterone at the mineralocorticoid receptor, 7.5% that of cortisol at the glucocorticoid receptor, and <0.02% that of estradiol at the estrogen receptor.[2]

Usage

Oral contraception

At low doses, levonorgestrel is used in monophasic and triphasic formulations of combined oral contraceptive pills, with available monophasic doses ranging from 100-250 µg, and triphasic doses of 50 µg/75 µg/125 µg.

At very low daily dose of 30 µg, levonorgestrel is used in some progestogen only pill formulations.

Emergency contraception

Levonorgestrel is used in emergency contraceptive pills (ECPs), both in a combined Yuzpe regimen which includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1500 μg (as a single dose or as two 750 μg doses 12 hours apart) taken within 3 days of unprotected sex. There are many brand names of levonorgestrel-only ECPs, including: Escapelle, Plan B, Levonelle, NorLevo, Postinor-2, i-pill and 72-HOURS.[3]

Intrauterine system

Levonorgestrel is the active ingredient in the Mirena intrauterine system.

Contraceptive implants

Levonorgestrel is the active ingredient in Norplant and Jadelle.

References

  1. ^ Edgren RA, Stanczyk FZ (1999). "Nomenclature of the gonane progestins". Contraception 60 (6): 313. doi:10.1016/S0010-7824(99)00101-8. PMID 10715364. 
  2. ^ Sitruk-Ware R (2006). "New progestagens for contraceptive use". Hum Reprod Update 12 (2): 169–78. doi:10.1093/humupd/dmi046. PMID 16291771. 
  3. ^ Trussell, James; Cleland, Kelly (2007-04-10). "Emergency Contraceptive Pills Worldwide". Princeton University. http://ec.princeton.edu/questions/dedicated.html. Retrieved 2007-05-28. 

External links


 
 

 

Copyrights:

Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved.  Read more
Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Levonorgestrel" Read more