
n.
The levorotatory form of norgestrel, used in oral contraceptives and in contraceptives implanted subdermally. In implant form it can prevent pregnancy for up to five years.
| Dictionary: le·vo·nor·ges·trel |

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| Drug Info: Levonorgestrel |
Brand names: Mirena®Norplant®Plan B®
Chemical formula:

Levonorgestrel implant capsules
What are levonorgestrel implant capsules?
LEVONORGESTREL (Norplant®) is a contraceptive (birth control) device that is surgically implanted under the skin. The device releases the hormone levonorgestrel, a progestin, in the body to prevent pregnancy for up to 5 years. Once the implant capsules are removed, fertility quickly returns to normal. Generic levonorgestrel implant capsules are not yet available. NOTE: Norplant® is discontinued in the US as of mid-2002.What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:How should I use this medicine?
Levonorgestrel implant capsules are surgically implanted under the skin by a health-care professional.What if I miss a dose?
This does not apply.What drug(s) may interact with levonorgestrel?
What should I watch for while taking levonorgestrel?
Visit your prescriber or health care professional for regular checks on your progress. You should have a complete check-up every 6 to 12 months.What side effects may I notice from using levonorgestrel?
Side effects that you should report to your prescriber or health care professional as soon as possible:Where can I keep my medicine?
This does not apply.Last updated: 8/19/2004 10:51:00 AM
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
| Wikipedia: Levonorgestrel |
| Systematic (IUPAC) name | |
|---|---|
| 13-ethyl-17-ethynyl-17-hydroxy- 1,2,6,7,8,9,10,11,12,13,14,15,16, 17- tetradecahydrocyclopenta[a] phenanthren-3-one | |
| Identifiers | |
| CAS number | 797-63-7 |
| ATC code | G03AC03 |
| PubChem | 13109 |
| DrugBank | APRD00754 |
| ChemSpider | 12560 |
| Chemical data | |
| Formula | C21H28O2 |
| Mol. mass | 312.446 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ~100% |
| Protein binding | 55% |
| Metabolism | Hepatic |
| Half life | 36 ± 13 hours |
| Excretion | Renal: 45%; Fecal:32% |
| Therapeutic considerations | |
| Pregnancy cat. |
X |
| Legal status | |
| Routes | Implant; insert (extended-release); oral |
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Levonorgestrel (or l-norgestrel or D-norgestrel) is a synthetic progestogen used as an active ingredient in some hormonal contraceptives.
Contents |
Chemically, it is a hormonally active levorotatory enantiomer of the racemic mixture norgestrel. It is a gonane progestin derived from 19-nortestosterone.[1]
Its in vitro relative binding affinities at human steroid hormone receptors are: 323% that of progesterone at the progesterone receptor, 58% that of testosterone at the androgen receptor, 17% that of aldosterone at the mineralocorticoid receptor, 7.5% that of cortisol at the glucocorticoid receptor, and <0.02% that of estradiol at the estrogen receptor.[2]
At low doses, levonorgestrel is used in monophasic and triphasic formulations of combined oral contraceptive pills, with available monophasic doses ranging from 100-250 µg, and triphasic doses of 50 µg/75 µg/125 µg.
At very low daily dose of 30 µg, levonorgestrel is used in some progestogen only pill formulations.
Levonorgestrel is used in emergency contraceptive pills (ECPs), both in a combined Yuzpe regimen which includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1500 μg (as a single dose or as two 750 μg doses 12 hours apart) taken within 3 days of unprotected sex. There are many brand names of levonorgestrel-only ECPs, including: Escapelle, Plan B, Levonelle, NorLevo, Postinor-2, i-pill and 72-HOURS.[3]
Levonorgestrel is the active ingredient in the Mirena intrauterine system.
Levonorgestrel is the active ingredient in Norplant and Jadelle.
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![]() | Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved. Read more | |
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