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yes an antigen can have more than one epitope

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yes an antigen can have more than one epitope

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epitope

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Antigen binding site or epitope is a part of an antigen that is recognized by the antibody.

Paratope is a part of an antibody that binds on epitope.

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The immune cells do not recognize an entire immunogen molecule, instead the lymphocytes recognize the unique individual chemical groups or discrete & specific sites having three-dimensional shape on the macromolecules, called epitopes.

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Polyclonal antibody recognizes several epitopes on the target protein while monoclonal antibody recognizes only single epitope. Sometimes, monoclonal antibodies are not able to precipitate the antigen because the epitope might need to be exposed on the surface of the antigen to be recognized by the antibody. Since the epitope might be hidden and it's a single epitope that is recognized by the monoclonal antibody, the propability of the antibody to reconize the epitope is lower compared with the polyclonal antibody that recognizes several epitopes on the target protein.

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