(medicine) A disturbance of fat metabolism in which the subcutaneous fat disappears over some regions of the body, but is unaffected in others.
Lipodystrophy
| Sci-Tech Dictionary: lipodystrophy |
(′lip·ə′dis·trə·fē)
| 5min Related Video: Lipodystrophy |
| Food and Nutrition: lipodystrophy |
Abnormal pattern of subcutaneous fat deposits.
| Dental Dictionary: lipodystrophy |
n
Any abnormality in the metabolism or deposition of fats.
| Veterinary Dictionary: lipodystrophy |
Any disturbance of fat metabolism.
- porcine cerebrospinal l. — see GM2 gangliosidosis.
| Wikipedia: Lipodystrophy |
| Lipodystrophy | |
| Classification and external resources | |
| ICD-10 | E88.1 |
|---|---|
| ICD-9 | 272.6 |
| DiseasesDB | 30066 |
| eMedicine | med/1307 med/3523 |
| MeSH | [1] |
Lipodystrophy is a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue. ("Lipo" is Greek for "fat" and "dystrophy" is Greek for "abnormal or degenerative condition".) A more specific term, lipoatrophy is used when describing the loss of fat from one area (usually the face).
Contents |
Types
Lipodystrophy may be divided into the following types:[1]:495-7
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- Congential lipodystrophies
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- Congenital generalized lipodystrophy (Beradinelli-Seip syndrome)
- Familial partial lipodystrophy
- Acquired lipodystrophy
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- Acquired partial lipodystrophy (Barraquer-Simons syndrome)
- Acquired generalized lipodystrophy
- Centrifugal abdominal lipodystrophy (Lipodystrophia centrifugalis abdominalis infantilis)
- Lipoatrophia annularis (Ferreira-Marques lipoatrophia)
- Localized lipodystrophy
- HIV-associated lipodystrophy
Insulin injections
A lipodystrophy can be a lump or small dent in the skin that forms when a person keeps performing injections in the same spot. These types of lipodystrophies are harmless. People who want to avoid them can do so by changing (rotating) the places where they perform injections. For people with diabetes, using purified insulins may also help.
One of the side-effects of lipodystrophy is the rejection of the injected medication, the slowing down of the absorption of the medication, or trauma that can cause bleeding that, in turn, will reject the medication. In either scenarios, the dosage of the medication, such as insulin for diabetics, becomes impossible to gauge correctly and the treatment of the disease for which the medication is administered is impaired thereby allowing the medical condition to worsen.
In some cases, rotation of the injection sites may not be enough to prevent lipodystrophy.
Antiretroviral drugs
Lipodystrophies can be a possible side effect of antiretroviral drugs. Other lipodystrophies manifest as lipid redistribution; with excess, or lack of, fat in various regions of the body. These include, but are not limited to, having sunken cheeks and/or "humps" on the back or back of the neck (also referred to as buffalo hump).[2]
Hereditary forms
Lipodystrophy can be caused by metabolic abnormalities due to genetic issues. These are often characterized by insulin resistance and are associated with Metabolic Syndrome.
References
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ Physical and Biochemical Changes in HIV Disease Eric S. Daar, M.D. MedicineNet, Accessed 22 September 2007
External links
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 | Sci-Tech Dictionary. McGraw-Hill Dictionary of Scientific and Technical Terms. Copyright © 2003, 1994, 1989, 1984, 1978, 1976, 1974 by McGraw-Hill Companies, Inc. All rights reserved. Read more |
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| Food and Nutrition. A Dictionary of Food and Nutrition. Copyright © 1995, 2003, 2005 by A. E. Bender and D. A. Bender. All rights reserved. Read more |
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| Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved. Read more |
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| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Lipodystrophy". Read more |
