Liquefactive necrosis (or colliquative necrosis) is a type of necrosis which is characteristic of focal bacterial or fungal infections. In liquefactive necrosis, the affected cell is completely digested by hydrolytic enzymes, resulting in a soft, circumscribed lesion consisting of pus and the fluid remains of necrotic tissue. After the removal of cell debris by white blood cells, a fluid filled space is left. It is generally associated with abscess formation and is commonly found in the central nervous system.
In the brain
For unclear reasons, hypoxic death of cells within the central nervous system also results in liquefactive necrosis.(Brain Infarction => Emollition) This is a process in which lysosomes turn tissues into soup as a result of lysosomal release of digestive enzymes in the face of bacterial onslaught. Loss of tissue architecture means that the tissue is essentially liquefied. The affected area is soft with liquefied centre containing necrotic debris. Later, a cyst wall is formed. Microscopically, the cystic space contains necrotic cell debris and macrophages filled with phagocytosed material. The cyst wall is formed by proliferating capillaries, inflammatory cells, and gliosis (proliferating glial cells) in the case of brain and proliferating fibroblasts in the case of abscess cavity.
In the lung
Liquefactive necrosis can also occur in the lung.[1][2]
References
- ^ "Cell Injury". http://library.med.utah.edu/WebPath/CINJHTML/CINJ020.html. Retrieved 2009-05-15.
- ^ Quaia E, Baratella E, Pizzolato R, Bussani R, Cova MA (March 2009). "Radiological-pathological correlation in intratumoural tissue components of solid lung tumours". Radiol Med 114 (2): 173–89. doi:. PMID 19082781. http://dx.doi.org/10.1007/s11547-008-0354-6.
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