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Their are 2 main guys he fights, in the comics Titanium man, in the movie Iron monger, those are his 2 main enemies.
he has a suit that protects him. It makes him fly and helps defend him from enemies
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In the comics, it's the Mandarin, who can also be seen in the tv-series "Iron Man: Armored Adventures"
The mandarin is also believed to be the main villain for Iron Man 3 coming out in 2013
It's true, Nixon had an enemies list.