Lomerizine

Lomerizine

Systematic (IUPAC) name
1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	101477-55-8 Y
ATC code	None
PubChem	CID 3949
UNII	DEE37CY4VO N
ChEMBL	CHEMBL29188 N
Chemical data
Formula	C27H30F2N2O3
Mol. mass	468.53 g/mol
SMILES	eMolecules & PubChem
N(what is this?)  (verify)

Lomerizine (INN) is a calcium channel blocker^[1] with antimigraine properties.

References

1. ^ Selt M, Bartlett CA, Harvey AR, Dunlop SA, Fitzgerald M (November 2009). "Limited restoration of visual function after partial optic nerve injury; a time course study using the calcium channel blocker lomerizine". Brain Res. Bull. 81 (4–5): 467–471. doi:10.1016/j.brainresbull.2009.11.004. PMID 19913075. http://linkinghub.elsevier.com/retrieve/pii/S0361-9230(09)00354-2. 

v · d · eAntimigraine preparations (N02C) Analgesic/abortive Serotonin modulators Ergot alkaloids Dihydroergotamine • Ergotamine • Methysergide • Lisuride 5-HT1 agonists Triptans (Almotriptan, Avitriptan, Eletriptan, Frovatriptan, Naratriptan, Rizatriptan, Sumatriptan, Zolmitriptan) Alniditan Other Dotarizine Other Paracetamol# • Amidrine Prevention of migraines Beta blocker Propranolol# • Timolol CCB verapamil corticosteroid flumedroxone monosaccharide topiramate adrenergic agonist Clonidine tricyclic antidepressant amitriptyline • nortriptyline • imipramine anticonvulsant valproate • carbamazepine • oxcarbazepine Ungrouped Pizotifen • Iprazochrome • Dimetotiazine • Oxetorone • Lomerizine • Telcagepant #WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III M: CNS anat(n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp noco(m/d/e/h/v/s)/cong/tumr, sysi/epon, injr proc, drug(N1A/2AB/C/3/4/7A/B/C/D)

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