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Lopirazepam

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Lopirazepam

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Lopirazepam
Systematic (IUPAC) name
(RS)-7-chloro- 5-(2-chlorophenyl)- 3-hydroxy- 1,3-dihydro- 2H- pyrido [3,2-e] [1,4] diazepin- 2-one
Clinical data
Pregnancy cat. D
Legal status Schedule IV (US)
Routes Oral
Identifiers
CAS number 42863-81-0
ATC code None
PubChem CID 68672
ChemSpider 61926
UNII 8PDI6DY6GV YesY
Chemical data
Formula C14H9Cl2N3O2 
Mol. mass 322.146 g/mol
SMILES eMolecules & PubChem

Lopirazepam (INN)[1] is a short-acting benzodiazepine analog of the pyridodiazepine type (specifically, the pyridodiazepine analog of lorazepam) with anxiolytic and hypnotic properties.[2][3] It has never been marketed.[4]

See also

References

  1. ^ US Patent 4008223
  2. ^ Saletu M, Saletu B, Grünberger J, Mader R, Karobath M (1983). "Clinical symptomatology and computer analyzed EEG before, during and after anxiolytic therapy of alcohol withdrawal patients". Neuropsychobiology 9 (2–3): 119–34. doi:10.1159/000117949. PMID 6353268. 
  3. ^ Fabian A, Röhmel R, Kubicki S (September 1984). "[Changes in the length of sleep cycles during administration of flurazepam and lopirazepam]" (in German). EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb 15 (3): 151–8. PMID 6435999. 
  4. ^ David J. Triggle; C. R. Ganellin, F. MacDonald (1996). Dictionary of Pharmacological Agents. 2. Boca Raton: Chapman & Hall/CRC. p. 1232. ISBN 0-412-46630-9. http://books.google.com/?id=A0THacd46ZsC&pg=PA1232&lpg=PA1232.  Retrieved on December 31, 2008 through Google Book Search.
Benzodiazepine derivatives
1,4-Benzodiazepines
1,5-Benzodiazepines
2,3-Benzodiazepines *
Triazolobenzodiazepines
Imidazobenzodiazepines
Oxazolobenzodiazepines
Thienodiazepines
Pyridodiazepines
Pyrazolodiazepines
Pyrrolodiazepines
Tetrahydroisoquinobenzodiazepines
Benzodiazepine prodrugs
* atypical activity profile (not GABAA receptor ligands)


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