LOXL4
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| Lysyl oxidase-like 4 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | LOXL4; FLJ21889; LOXC | ||||||||||
| External IDs | OMIM: 607318 MGI: 1914823 HomoloGene: 12977 GeneCards: LOXL4 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 84171 | 67573 | |||||||||
| Ensembl | ENSG00000138131 | ENSMUSG00000025185 | |||||||||
| UniProt | Q96JB6 | Q6NV59 | |||||||||
| RefSeq (mRNA) | NM_032211 | NM_053083 | |||||||||
| RefSeq (protein) | NP_115587 | NP_444313 | |||||||||
| Location (UCSC) | Chr 10: 100 - 100.02 Mb |
Chr 19: 42.65 - 42.67 Mb |
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| PubMed search | [1] | [2] | |||||||||
Lysyl oxidase homolog 4 is an enzyme that in humans is encoded by the LOXL4 gene.[1][2]
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.[2]
See also
References
- ^ Ito H, Akiyama H, Iguchi H, Iyama K, Miyamoto M, Ohsawa K, Nakamura T (Jun 2001). "Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage". J Biol Chem 276 (26): 24023–9. doi:10.1074/jbc.M100861200. PMID 11292829.
- ^ a b "Entrez Gene: LOXL4 lysyl oxidase-like 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84171.
Further reading
- Molnar J, Fong KS, He QP, et al. (2003). "Structural and functional diversity of lysyl oxidase and the LOX-like proteins". Biochim. Biophys. Acta 1647 (1-2): 220–4. PMID 12686136.
- Asuncion L, Fogelgren B, Fong KS, et al. (2002). "A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain". Matrix Biol. 20 (7): 487–91. doi:10.1016/S0945-053X(01)00161-5. PMID 11691588.
- Mäki JM, Tikkanen H, Kivirikko KI (2002). "Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains". Matrix Biol. 20 (7): 493–6. doi:10.1016/S0945-053X(01)00157-3. PMID 11691589.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Holtmeier C, Görögh T, Beier U, et al. (2003). "Overexpression of a novel lysyl oxidase-like gene in human head and neck squamous cell carcinomas". Anticancer Res. 23 (3B): 2585–91. PMID 12894545.
- Kim MS, Kim SS, Jung ST, et al. (2004). "Expression and purification of enzymatically active forms of the human lysyl oxidase-like protein 4". J. Biol. Chem. 278 (52): 52071–4. doi:10.1074/jbc.M308856200. PMID 14551188.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Shieh TM, Lin SC, Liu CJ, et al. (2007). "Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis". Clin. Cancer Res. 13 (15 Pt 1): 4378–85. doi:10.1158/1078-0432.CCR-06-2685. PMID 17671119.
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