LPHN3
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| Latrophilin 3 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | LPHN3; CIRL3; LEC3 | ||||||||||||
| External IDs | MGI: 2441950 HomoloGene: 22878 GeneCards: LPHN3 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 23284 | 319387 | |||||||||||
| Ensembl | ENSG00000150471 | ENSMUSG00000037605 | |||||||||||
| UniProt | Q9HAR2 | Q80TS3 | |||||||||||
| RefSeq (mRNA) | NM_015236 | NM_198702.2 | |||||||||||
| RefSeq (protein) | NP_056051 | NP_941991.1 | |||||||||||
| Location (UCSC) | Chr 4: 62.07 – 62.94 Mb |
Chr 5: 81.45 – 82.25 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Latrophilin-3 is a protein that in humans is encoded by the LPHN3 gene.[1][2]
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Contents
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Function
This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.[2]
Clinical significance
A version of this gene has been linked to Attention Deficit/Hyperactivity Disorder (ADHD).[3]
See also
References
- ^ Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". J Recept Signal Transduct Res 20 (2–3): 119–31. doi:10.3109/10799890009150640. PMID 10994649.
- ^ a b "Entrez Gene: LPHN3 latrophilin 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23284.
- ^ Arcos-Burgos M, Jain M, Acosta MT, et al. (November 2010). "A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication". Mol. Psychiatry 15 (11): 1053–66. doi:10.1038/mp.2010.6. PMID 20157310. https://mail.nyu.edu/attach/Arcos-Burgos%20et%20al.%202010.pdf?sid=mSwUWyHz8dM&mbox=INBOX&uid=71290&number=2&filename=Arcos-Burgos%20et%20al.%202010.pdf.
Further reading
- Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annu. Rev. Neurosci. 24: 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.
- Ushkaryov YA, Volynski KE, Ashton AC (2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.
- Soares MB, Bonaldo MF, Jelene P, et al. (1994). "Construction and characterization of a normalized cDNA library". Proc. Natl. Acad. Sci. U.S.A. 91 (20): 9228–32. doi:10.1073/pnas.91.20.9228. PMC 44785. PMID 7937745. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=44785.
- "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
- Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". J. Biol. Chem. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
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